18F-氟代脱氧葡萄糖 PET／CT 在寻找多发性骨转移瘤原发灶中的应用  

Diagnostic value of 18F -FDG PET -CT in looking for tumor primary lesion with multiple bone metastasis

作　　者：沈小东[1] 潘建虎[1] 陈泯涵 李金柱[1] 黄华英[1] 

机构地区：[1]解放军第一一七医院PET-CT中心,浙江省杭州310000

出　　处：《中国基层医药》2015年第12期1872-1874,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：评估18F-氟代脱氧葡萄糖（18F-FDG）PET／CT在寻找多发性骨转移瘤原发灶中的临床价值。方法选择行常规影像学检查（X 线、CT、MRI）疑诊为骨转移瘤的患者84例，利用18F-FDG PET／CT寻找原发灶。患者的最终诊断通过组织病理学或临床及影像学检查随访证实。统计18F-FDG PET／CT 对骨转移瘤的诊断灵敏度、特异性、准确性。结果在84例患者中，18F-FDG PET／CT 发现原发灶49例，其中46例（54．8％）经手术或病理证实为原发灶，另外3例为假阳性；PET／CT 诊断为非骨转移瘤的35例患者，最终病理和随访证实34例为非骨转移瘤；18F-FDG PET／CT 对骨转移瘤诊断的灵敏度、特异性、准确性分别为54．8％（46／84）、93．9％（46／49）和95．2％（80／84）；原发灶包括肺癌18例，前列腺癌9例，乳腺癌7例，淋巴瘤5例，肾癌4例，肝癌2例，子宫肉瘤1例。结论18F-FDG PET／CT 在寻找多发性骨转移瘤原发灶具有较高的特异性、准确性，对原发灶具有较高的检出率，有利于临床上综合治疗方案的制定。Objective To evaluate the diagnostic value of 18F-FDG PET-CT in looking for tumor primary lesion with multiple bone metastasis.Methods 84 patients with suspected bone metastases were detected by routine imaging （X -ray,CT,MRI）in our hospital from May 2012 to September 2014 were selected,18F -FDG PET/CT were used to find the primary lesion.The final diagnosis were confirmed by tissue pathology or by clinical imaging follow -up.The diagnostic sensitivity,specificity and accuracy on tumor bone metastasis of 18F -FDG PET/CT were recorded.Results In 84 patients,primary tumor was found in 49 cases,of which 46 cases （54.8%）confirmed pri-mary tumor by operation or pathology,the other 3 cases were false positive;35 patients were diagnosed as non meta-static bone tumor by PET/CT,in which 34 cases were finally confirmed as non metastatic bone tumor by pathology and follow -up;accuracy,sensitivity,specificity of 18F -FDG PET/CT were 54.8%（46 /84）,93.9% （46 /49）and 95.2%（80 /84）;18 cases of lung cancer,9 cases of prostate cancer,7 cases of breast cancer,5 cases of lymphoma, 4 cases of renal cell carcinoma,2 cases of liver cancer,1 cases of Uterine sarcoma were included in 46 primary tumors.Conclusion 18F -FDG PET/CT has a higher specificity,accuracy as well as higher detection rate in search of multiple bone metastases,thus it is beneficial to the clinical therapy.

关 键 词：氟脱氧葡萄糖F18 多发性骨转移瘤 

分 类 号：R730.44[医药卫生—肿瘤] R738.1[医药卫生—临床医学]