神经营养因子功能的“阴/阳”特性  

The "Yin / Yang" Functional Features of Neurotrophic Factors

作　　者：孙晓龙[1,2] 段丽[1] 焦西英[1] 陈良为[1] 

机构地区：[1]第四军医大学神经生物学教研室,西安710032 [2]第四军医大学西京医院神经内科,西安710032

出　　处：《生理科学进展》2015年第3期170-174,共5页Progress in Physiological Sciences

基　　金：国家973项目(2011CB504103);国家自然科学基金(31371374)资助课题

摘　　要：神经营养因子是一类对神经元的营养、支持、分化及突触可塑性等具有重要作用的蛋白质。近年来研究发现神经营养因子合成中的前体分子产生相反的诱导神经元凋亡作用,并在中枢退行性疾病发生中扮演着重要的角色。本文综述了神经营养因子及其前体蛋白在合成代谢、受体调控和功能上的"阴/阳"特性,并讨论其在疾病过程中的可能作用,为进一步探索认识神经营养因子的功能、病理意义、疾病治疗价值提供新的视角。Neurotrophic factor is a kind of protein family that plays an important role in the nutrition,support and differentiation to central neurons as well as synaptic plasticity. Growing evidences have revealed that pro-forms of various neurotrophic factors,which are generated in process of protein synthesis and might exert opposite roles involving in inducement of neuronal apoptosis and implication in pathogenesis of neurodegenerative diseases. This paper reviews ＂ Yin / Yang＂ features of neurotrophic factors in the anabolism,receptor regulation,functional aspects,and their related role in pathogenesis of neurodegenerative diseases. It is hopefully to provide new idea on understanding and investigation of the neurotrophic factors regarding on their functional,pathological and potential therapeutic significance.

关 键 词：神经营养因子 中枢神经系统 “阴/阳”特性 

分 类 号：Q42[生物学—神经生物学]