帕金森病中铁与Alpha-突触核蛋白的相互作用  

The Role of Iron and Alpha-synuclein Interacting in Parkinson's Disease

作　　者：王俊[1] 宋宁[1] 徐华敏[1] 姜宏[1] 谢俊霞[1] 

机构地区：[1]青岛大学医学院生理教研室,山东省神经相关疾病重点实验室,山东省神经退变疾病协同创新中心,国家生理学重点培育学科,青岛266071

出　　处：《生理科学进展》2015年第3期180-184,共5页Progress in Physiological Sciences

基　　金：国家自然科学基金重点项目(81430024);国家重点基础研究发展973计划(2011CB504102);山东省“泰山学者”资助课题

摘　　要：帕金森病(Parkinson's disease,PD)的特异标志物Alpha-突触核蛋白的异常聚集往往伴有铁的沉积,说明铁与Alpha-突触核蛋白聚集之间存在一定联系。铁可以通过增加Alpha-突触核蛋白的产生及抑制其降解从而促进Alpha-突触核蛋白聚集。Alpha-突触核蛋白作为一种高铁还原酶也可以影响细胞铁的代谢。本文就铁与Alpha-突触核蛋白参与PD的发病以及两者之间相互作用的机制进行综述。Both iron and alpha-synuclein accumulation are one of hallmarks of Parkinson ＇s disease（ PD）. Alpha-synuclein aggregation is often accompanied by abnormal accumulation of iron,indicating that there is a certain link between iron and alpha-synuclein aggregation. Iron promotes alpha-synuclein aggregation by increasing its synthesis and decreasing its degradation. Also,alpha-synuclein regulates iron metabolism through its ferrireductase activity. In this review,we will describe the roles of iron and alpha-synuclein in PD pathogenesis,and the mechanisms of iron and alpha-synuclein interaction.

关 键 词：帕金森病 铁 Alpha-突触核蛋白 

分 类 号：R338[医药卫生—人体生理学] R742[医药卫生—基础医学]