芪藤地黄颗粒联合雷公藤多甙片治疗Ⅳ期糖尿病肾病的研究  

Clinical study of Qi Teng Dihuang granule combined with Tripterygium Wilfordii Polyglucosides on diabetic nephropathy stage IV

作　　者：王小强[1] 刘刚[1] 

机构地区：[1]北京市怀柔区中医医院,北京101400

出　　处：《现代中西医结合杂志》2015年第19期2060-2064,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：北京中医药大学东直门医院医疗管理集团科研交流与合作项目(2011YLJT-020)

摘　　要：目的观察芪藤地黄颗粒联合雷公藤多甙片治疗Ⅳ期糖尿病肾病的临床疗效。方法将72例Ⅳ期糖尿病肾病患者随机分为联合组、中药组、西药组,每组24例。各组均给予饮食控制、降糖、降脂、降压等基础治疗,在此基础上,联合组给予芪藤地黄颗粒联合雷公藤多甙片治疗,中药组给予芪藤地黄颗粒治疗,西药组给予缬沙坦胶囊治疗,均治疗6个月。分别记录治疗前及治疗后1,3,6个月3组临床症状积分、24 h尿蛋白定量、肌酐、肾小球滤过率、生活质量评分,并计算尿蛋白下降百分率、肌酐升高百分率,肾小球滤过率下降百分率及肾功能进展的比例。结果联合组临床疗效及症状疗效均明显优于中药组及西药组(P均<0.05),中药组疗效又明显优于西药组(P<0.05)。治疗后联合组24 h尿蛋白定量下降及生活质量评分升高情况均明显优于中药组(P均<0.05),中药组又优于西药组(P均<0.05);联合组和中药组血肌酐、肾小球滤过率、症状均明显改善,但组间比较差异均无统计学意义(P均>0.05);西药组各指标治疗前后比较差异均无统计学意义(P均>0.05)。结论芪藤地黄颗粒联合雷公藤多甙片治疗Ⅳ期糖尿病肾病疗效优于单独应用中药及西药,但需进一步深入研究。Objective It is to study the clinical curative effect of Qi Teng Dihuang granule combined with Tripterygium Wilfordii Polyglucosides on diabetic nephropathy stage IV. Methods 72 cases of diabetic nephropathy stage Ⅳ were randomly divided into combination group, Chinese medicine group and western medicine group, each group had 24 cases. Every group received dietary control, hypoglycemic, lipid-lowering, antihypertensive and other basic therapy. In addition, the combination group was treated by Qi Teng Dihuang granule combined with Tripterygium wilfordii, traditional Chinese medicine group was treated by QiTeng Dihuang granule alone,while the western medicine group was treated by Valsartan capsules alone, period of treatment was 6 months. Finally, clinical symptoms, 24 hours urine protein, serum creatinine, estimated glomerular filtration rate and quality of life scale score before treatment, after treatment for 1 months, 3 months and 6 months were recorded. The percentage of decreased urinary protein, creatininepercentage, the percentage decline in glomerular filtration rate and renal function of the proportion of progress were calculated. Results The efficacy of the combination group was significantly better than that of the traditional Chinese medicine group and western medicine group（P 〈 0.05） , while that of the traditional Chinese medicine group was better than western medicine group （P 〈 0. 05）. The combination group was significantly better than the traditional Chinese medicine group and the Chinese medicine treatment group was better than western medicine treatment group in decreasing 24 hours urine protein and increasing quantity and quality of life score （ P 〈 0.05 ）. The efficacy of the combination group was the same with the traditional Chinese medicine group in declining creatinine, increasing glomerular filtration rate and improving symptoms. The western medicine treatment group compared with those before treatment had no obvious effect. Conclusion Qi Teng Dihuang granule combined

关 键 词：芪藤地黄颗粒 雷公藤多甙片 Ⅳ期糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]