甲磺酸加替沙星的化学结构分析  

Chemical structural analysis of gatifloxacin mesylate

作　　者：黄琦[1] 

机构地区：[1]浙江科技学院生物与化学工程学院,杭州310023

出　　处：《浙江科技学院学报》2015年第3期168-173,240,共7页Journal of Zhejiang University of Science and Technology

基　　金：浙江省公益性技术应用研究计划项目(2015C37072)

摘　　要：建立药物甲磺酸加替沙星化学结构的确证方法。通过热分析(TA)、元素分析(EA)、紫外吸收光谱(UV)、红外吸收光谱(IR)、质谱(MS)、X-射线粉末衍射(XRD)及核磁共振(NMR)等分析手段,对甲磺酸加替沙星样品进行结构确证。证实了甲磺酸加替沙星的结构为1-环丙基-6氟-1,4-二氢-8-甲氧基-7-(3-甲基-1-哌嗪基)-4-氧-3-喹啉羧酸甲磺酸盐。该方法准确、可行,从而为甲磺酸加替沙星的生产和鉴定提供了较全面的参考依据。A method for the determination of the chemical structure of gatifloxacin mesylate was established. Thermal analysis （TA）, elemental analysis （EA）, ultraviolet absorption spectrum （UV）, infrared Fourier transform spectroscopy （FT-IR）, mass spectrometry （MS）, X-ray powder diffraction（XRD） and nuclear magnetic resonance（NMR） were adopted to analyze the chemical structure of gatifloxacin mesylate. All the ~ H NMR and 13C NMR chemical shifts were assigned by means of 1 H-1^ H COSY, HMBC and HMQC. The chemical structure of gatifloxacin mesylate is 1-cyelopropyl-6-fluoro-1,4-dibydro-8-methoxy -7-（3-methyl-l-piperazinyl）-4-oxo-3- quinolinecarboxylic acid mesylate. The result of the method is accurate, general and can provide a comprehensive reference for production and identification of gatifloxacin mesvlate.

关 键 词：甲磺酸加替沙星 化学结构分析 光谱分析 

分 类 号：R917[医药卫生—药物分析学]