非瓣膜病性心房颤动患者血脂水平的临床研究  

The clinical research about lipid levels of atrial fibrillation in the non valvular disease

作　　者：曾国良[1] 彭健[2] 罗伶俐[1] 刘明[1] 冯新武[1] 

机构地区：[1]广东省肇庆市第一人民医院心内科,526000 [2]南方医科大学附属南方医院,广州510515

出　　处：《检验医学与临床》2015年第12期1697-1699,共3页Laboratory Medicine and Clinic

基　　金：广州市科技计划项目(201300000146)

摘　　要：目的探讨非瓣膜病性心房颤动患者血脂水平,并研究其与非瓣膜病性心房颤动的关系。方法2011年1月至2013年8月在肇庆市第一人民医院的心房颤动患者148例作为房颤组,另外选取的窦性心律患者56例作为对照组,检测2组患者血脂水平并分析比较其变化。结果房颤组患者高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)和载脂蛋白B(ApoB)明显低于对照组,差异有统计学意义(P<0.05),HDL-C与阵发性心房颤动(PAF)组呈负相关,LDL-C与慢性心房颤动(NPAF)组呈负相关。结论 HDL-C、LDL-C与心房颤动相关,血浆HDL-C、LDL-C水平降低可能是心房颤动的诱发因素之一,并参与其发生、发展过程。Objective To observe the blood lipid level with satrial fibrillation in the non valvular disease,and analyse the ralationship of blood lipid levels and nonvalvular atrial fibrillation.Methods 148 patients with atrial from January 2011 to August 2013 in the hospital were collected as atrial fibrillation group,and 56 patients with sinus rhythm were selected as the control group.The lipid levels in the two groups were determined and analized.ResultsHigh density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）,apolipoprotein Al（apoA I）and apolipoprotein B（apoB）in patients with atrial fibrillation group were lower than those of the control group（P〈0.05）.HDL was negatively correlated with PAF group,LDL was negatively correlated with NPAF group.Conclusion HDL,LDL were correlated with atrial fibrillation,the decrease of HDL,LDL may be the reason of atrial fibrillation.

关 键 词：心房颤动 低密度脂蛋白胆固醇 高密度脂蛋白胆固醇 总胆固醇 三酰甘油 

分 类 号：R541.750.5[医药卫生—心血管疾病]