利多卡因对AMI动物模型星状神经节内心交感神经元电活动的影响  

The effect of lidocaine on the electric activity of the cardiac sympathetic neurons in the stellate ganglion in AMI animal models

作　　者：陈卫[1] 井发强[2] 谭金明[2] 张晓芳[2] 岳文胜[3] 

机构地区：[1]川北医学院病理生理教研室,四川南充637100 [2]川北医学院机能实验中心,四川南充637100 [3]川北医学院附属医院超声科,四川南充637100

出　　处：《重庆医学》2015年第17期2327-2329,2332,共4页Chongqing medicine

基　　金：川北医学院重点培育项目(CBY11-A-ZP15)

摘　　要：目的该实验通过电生理技术记录急性心肌梗死(AMI)动物模型星状神经节内心交感神经元放电活动,并用不同剂量利多卡因干预以观察利多卡因对心交感神经元电活动的影响。方法成功复制AMI家兔动物模型后,在动物星状神经节内寻找到与心脏活动相关的放电神经元确定为心交感神经元,分成6组,耳缘静脉给予不同剂量利多卡因干预,观察比较心交感神经元放电的改变,同时同步记录Ⅱ导联心电图,明确二者之间关系。结果 87只新西兰大白兔的星状神经节内共记录到48个心交感神经元放电,实验发现AMI动物心交感神经即刻放电频率明显增加[(14.4±3.82)Hz增加到(24.3±5.52)Hz],P<0.05,经利多卡因干预后,随着给药剂量的加大,放电频率降低(P<0.05);Ⅱ导联心电图显示AMI动物心率加快[由(222.00±7.32)次/min上升到(289.00±10.51)次/min,P<0.05]。经利多卡因干预后心率减慢[(223.00±9.22)次/min降至192.00±12.18次/min,(P<0.05)];AMI动物ST段上抬且大于或等于2.5mm,经利多卡因干预后ST段上抬程度减小[(2.70±0.16)mm降至(1.10±0.44)mm,P<0.05]。结论利多卡因能明显抑制AMI动物星状神经节内心交感神经元放电,并能抑制因心肌缺血反射性的交感神经兴奋,心动过速,从而降低心肌耗氧量,减轻心肌缺血症状。Objective To record the electric activity of the cardiac sympathetic neurons in the stellate ganglion and investigate the effect of different doses of Lidocaine on this electric activity in AMI animal models.implementation.Methods AMI rabbits models were constructed successfully,then the cardiac sympathetic neurons recorded by the metal microelectrode in the stellate ganglion was divided into 6groups in order to research the effect of different doses of Lidocaine on the electric activity of the cardiac sympathetic neurons.The electrocardiogram（Lead Ⅱ）was demonstrated by BL-420 biological information processing system to confirm the relation with discharges of the cardiac sympathetic neurons.Results Forty-eight cardiac sympathetic neurons were recorded in the stellate ganglion in 87 AMI rabbits animal models.The discharge frequency of the cardiac sympatietic neurons in AMI animal models was exceeded these in normal animals[（14.4±3.82）Hz vs.（24.3±5.52）Hz,P〈0.05],but the neuronal discharges were restrained by Lidocaine,and higher dose of Lidocaine,the more restrained of neuronal discharge（P〈0.05）.In the AIM rabbits animals,the rates of heart added from（222±7.32）times/min to（289±10.51）times/min,but declined from（223.0±9.22）times/min to（192.00±12.18）times/min by the intravenous injection of Lidocaine;The raise degree of the ST section in Synchronous electrocardiogram was higher than 2.5mm,but the result was declined by Lidocaine[（2.7±0.16）mmvs.（1.1±0.44）mm,P〈0.05）]and the rates of heart increased.Conclusion The discharges frequency of the cardiac sympathetic neurons increasing in the stellate ganglion in AMI animal models and the excitement of sympathetic nerve can be inhibited by intravenous injection of Lidocaine to heart decrease rate and improve the symptom of myocardial ischemia.

关 键 词：利多卡因 星状神经节 心交感神经元 心肌梗死 

分 类 号：R614[医药卫生—麻醉学]