冠状动脉高血栓负荷的研究进展  

Research progress of high thrombus burden in coronary artery

作　　者：魏国清[1] 钱仁怡 孟照辉[1] 

机构地区：[1]昆明医科大学第一附属医院心内科分子心血管病研究室,云南昆明650032

出　　处：《临床医学》2015年第5期114-117,共4页Clinical Medicine

基　　金：国家自然科学基金资助项目(81160025);云南省应用基础研究重点项目(2012FB005);云南省中青年学术技术带头人后备人才资助项目(2011CI057);云南省教育厅重大专项项目(2D2010007)

摘　　要：冠状动脉高血栓负荷发生在ST段抬高型心肌梗死中,造成相关血管完全闭塞,导致相应区域心肌组织坏死。其病理基础多是由易损斑块的破裂、斑块糜烂和钙化结节糜烂导致;其后果是增加了介入治疗慢复流或无复流现象的发生及急性血栓事件发生的风险,从而增加心脏不良事件发生率。冠状动脉高血栓负荷的形成机制及处理措施是目前研究的热点、重点之一。国内外已进行了大量研究,该文通过文献复习做一简要综述。Intracoronary high thrombus burden occurs in ST-segment elevation myocardial infarction and causes related vas- cular occlusion, leading to corresponding regional myocardial tisstle necrosis. Its pathological basis including vulnerable plaque rupture, plaque erosion and calcified nodules erosion. It increased the occurrence of slow-flow and no-reflow phenomenon and the risk of acute thrombotic events after interventional treatment, thus increase the incidence of major adverse cardiac events. The formation mechanism of intracoronary high thrombus load and its treatment measures is currently one of research hot spots and fo- cus. There has been a lot of research both at home and abroad. This article mainly makes a summary through literature review.

关 键 词：冠状动脉高血栓负荷 斑块破裂 无复流 处理措施 

分 类 号：R543.3[医药卫生—心血管疾病]