溶栓胶囊防治急性高原病的效果观察  

Effect of Thrombolytic capsule in prevention and treatment of AHAD

作　　者：崔建华 张扬 李强 吴佩锋 王福领 李彬 

机构地区：[1]解放军18医院全军高山病防治研究中心 [2]解放军69214部队卫生队

出　　处：《西南国防医药》2015年第6期662-665,共4页Medical Journal of National Defending Forces in Southwest China

基　　金：高原医学教育部重点实验室资助项目(2011JSGY05);兰州军区高原科研攻关课题(LZ13GY04)

摘　　要：目的探讨溶栓胶囊防治急性高原病(AHAD)的效果。方法对急进4300 m高原的112名官兵分别口服溶栓胶囊(A组,n=32,0.25 g/粒,4粒/次)、复方红景天胶囊(B组,n=40,0.38 g/粒,2粒/次)和安慰剂(C组,n=40,炒面胶囊,2粒/次),每天早晚各服1次。进驻高原前3 d开始服药,进驻高原途中(4 d)及进驻后(8 d)连续服用,共服药15 d。进驻高原后第l、3、5、7 d检测Sa O2,并依据随访记录受试者每天的AHAD症状,然后分度评分。结果 A组与B组较C组第3、5、7 d的AHAD症状评分和发病率均降低,Sa O2增高(P<0.05或P<0.01);A组与B组AHAD症状评分无统计学差异(P>0.05),但A组对急性缺氧所致心慌、气短、胸闷、失眠等AHAD症状的发生率较B组和C组明显降低(P<0.05或P<0.01)。结论溶栓胶囊能改善AHAD症状,对缺氧所致心慌、气短、胸闷等症状防治效果优于复方红景天。To explore the effect of Thrombolytic capsules in prevention and treatment of the acute high altitude diseases （AHAD）. Total 112 army-men to be urgently deployed at the 4300 m high altitude were divided into three groups and orally took Thrombolytic capsules （group A, n = 32, 0.25 g per capsule, four capsules per time）, compound rhodiola capsules （group B, n = 40, 0.38g per capsule, two capsules per time） and placebo （group C, chow mein capsules, n = 40, two capsules per time） in the morning and evening every day. The medication lasted for 15 days including three days before the deployment, four days during the deployment and eight days after the deployment at high altitude. At the 1st, 3rd, 5th and 7th day after the deployment, their SaO2 were examined and then index scores were made according to AHAD symptoms of the subjects in the follow-up notes. Comparing with group C, AHAD symptom scores and disease occurrence rates at the 3rd, 5th and 7th day in group A and B were lower, but the SaO2 was higher （ P〈0.05 or P〈0.01）; AHAD symptom scores in group A and B had no statistic difference （ P〈0.05）, but the AHAD occurrence rate in group A, such as palpitation, hard breathe, chest choking sense and agrypnia, was significantly lower than that in group B and C （ P〈 0.05 or P〈0.01）. Thrombolytic capsule can improve AHAD symptoms, and compared with compound rhodiolae, it can also achieve a better effect in prevention of AHAD symptoms, such as palpitation, hard breathe, chest choking sense and agrypnia, resulted from oxygen deficit.

关 键 词：溶栓胶囊 复方红景天 急性高原病 防治 

分 类 号：R135.6[医药卫生—劳动卫生]