γ-干扰素和白介素-10在早期先兆流产合并绒毛膜下出血中的作用  

INTERFERON-γ AND INTERLEUKIN-10 IN BLOOD CHORIONIC WITH EARLY THREATENED ABORTION

作　　者：肖恒[1] 

机构地区：[1]广州中医药大学祈福医院,广东广州511495

出　　处：《现代医院》2015年第6期8-10,共3页Modern Hospitals

基　　金：广东省建设中医药强省项目(编号:20142024)

摘　　要：目的探讨早期先兆流产并绒毛膜下出血（SCH）患者血清中γ-干扰素（INF-1）、白介素-10（IL-10）及妊娠激素的变化及意义。方法30例孕5—9周先兆流产合并SCH患者为研究组，30例孕5～9N先兆流产无SCH患者为对照组I，30例孕5—9周正常妊娠孕妇为对照组Ⅱ。检测外周静脉血中β-人绒毛膜促性腺激素（β—HCG）、孕酮（P）、雌二醇（E2）的浓度，酶联免疫法（ELISA）检测血清INF-1和IL-10。结果研究组与对照组I血β—HCG、P、E2比较无统计学意义（P〉0．05），研究组血β—HCG、P、E2显著低于对照组Ⅱ，差异有统计学意义（P〈0．05）。研究组血清INF-γ显著高于对照组I及对照组Ⅱ，差异有统计学意义（P〈0．05）。研究组与对照组I血清IL-10比较差异无统计学意义（P〉0．05）。研究组血清IL-10显著低于对照组Ⅱ，差异有统计学意义（P〈0．05）。结论早期先兆流产合并SCH存在INF-γ增多，IL-10减少，INF-γ增多而IL-10缺乏可能是导致绒毛膜下出血的重要因素之一。Objective To study clinical significance of INF - γ, IL - 10 and Pregnancy hormonal changes in the serum of patients with early threatened abortion merged ehorionie hemorrhage （SCH）. Methods 30 cases of pregnant patients with threatened abortion and SCH 5 - 9 weeks for the study group ; 30 cases of patients with threat- ened abortion pregnant 5 - 9 weeks no SCH for the control group I; and 30 cases of 5 - 9 weeks gestation in normal pregnant women as control group II. The concentrations of β - HCG, progesterone （p） , estradiol （ E2 ） , INF - γand IL - 10 in peripheral venous blood were assayed with enzyme - linked immunosorbent assay （ELISA）. Results Pro- gesterone, estradiol and β - HCG had not statistical significance between the study group and the control group. β - HCG, Progesterone and E2 of the study group is significantly lower than the control group Ⅱ, and it had a statistically significant difference （p 〈 0.05 ）. INF - γ of the study group was significantly higher than control group II with statis- tical significance （p 〈 0.05 ）. IL - 10 of study group was significantly lower than the control group Ⅱ with statistical significance （p 〈 0.05 ）. Conclusion Increased INF - γ and reduced IL - 10 appeared in early threatened abortion with increased SCH. One of the important factors causing the ehorionic hemorrhage is the increased INF- γand re- duced IL - 10.

关 键 词：早期先兆流产 绒毛膜下出血 γ-干扰素白介素-10 

分 类 号：R714.21[医药卫生—妇产科学]