PTEN和P27蛋白的表达在食管上皮增生和癌变过程中的意义  

THE SIGNIFICANCE OF EXPRESSION OF PTEN AND P27 PROTEINS IN ESOPHAGEAL EPITHELIOSIS AND CARCINOGENESIS

作　　者：陈杰生[1] 吴名耀[2] 

机构地区：[1]汕头市澄海区人民医院,广东汕头515800 [2]汕头大学医学院病理学教研室,广东汕头515041

出　　处：《现代医院》2015年第6期17-19,共3页Modern Hospitals

摘　　要：目的研究食管黏膜上皮和癌旁组织中PTEN和P27蛋白的表达水平并探讨两种蛋白与食管癌发生的关系。方法应用免疫组化方法,对60例食管癌切除标本的上切缘正常黏膜、癌旁黏膜上皮和原位癌进行PTEN和P27蛋白表达的检测。结果 PTEN和P27蛋白在正常、增生和恶变的食管黏膜上皮细胞表达逐渐减少,两者在食管癌变过程中显示相同的分布模式。结论 PTEN和P27蛋白表达的改变与食管黏膜上皮的恶性转化密切相关,PTEN和P27蛋白表达缺失可能是一个有用的生物学标志和食管癌早期诊断的指标。Objective To investigate the expression of PTEN and P27 proteins in esophageal epitheliosis and carcinogenesis, and the relation to the development of esophageal carcinoma. Methods PTEN and P27 proteins ex- pression in 60 fresh tissue specimens, including esophageal mucosa above the upper surgical margin, carcinoma in si- tu and mucosa adjacent to tumor, were detected using immunohistochemical method. Results The expression of e- sophageal epithelial cells PTEN and P27 proteins in normal, hyperplastic and malignant gradually decreased, which showed a similar distribution pattern in esophageal carcinogenesis. Conclusion Malignant transformation expression change of PTEN and P27 proteins and esophageal mucosa are closely related, and the expression of PTEN and P27 proteins deletion may be a biological marker useful and esophageal cancer early diagnosis index.

关 键 词：PTEN P27 食管上皮 癌变过程 

分 类 号：R587.2[医药卫生—内分泌]