不同程度阿尔茨海默病患者血清可溶性Fas及其配体水平的变化  

Changes of serum concentrations of soluble Fas and soluble Fas ligand in patients with different degree Alzheimer disease

作　　者：陈同伟 

机构地区：[1]嘉善县中医医院检验科,浙江嘉善314100

出　　处：《检验医学》2015年第6期564-566,共3页Laboratory Medicine

摘　　要：目的探讨阿尔茨海默病(AD)患者血清可溶性Fas(s Fas)及其配体(s Fas L)水平的变化。方法选取AD患者100例,以54例老年疾病(包括糖尿病17例、高血压18例、高血脂15例、其它内分泌疾病4例)患者和46名健康体检者分别作为老年疾病对照组和正常对照组。采用酶联免疫吸附试验(ELISA)检测所有受检者血清s Fas、s Fas L水平,使用临床痴呆评定量表(CDR)、简易智能精神状态量表(MMSE)、Hachinski缺血指数量表(HIS)评定AD患者认知功能。结果 AD患者血清s Fas、s Fas L水平明显高于老年疾病对照组和正常对照组(P<0.01);随着病程加重,其血清s Fas、s Fas L水平逐渐升高。AD患者血清s Fas与年龄、病程和MMSE评分呈正相关(r=0.856、0.834、0.799,P<0.01),与Hachinski评分呈负相关(r=-0.714,P<0.01);血清s Fas L与年龄、病程呈正相关(r=0.863、0.857,P<0.01),与MMSE评分、HIS评分呈负相关(r=-0.801、-0.745,P<0.01)。结论 AD患者存在血清s Fas、s Fas L水平异常,提示AD患者在发病过程中可能存在神经细胞凋亡,且血清s Fas、s Fas L水平可能与患者的智能水平、脑缺血程度有关。Objective To investigate the changes of serum concentrations of soluble Fas（ sFas） and sFas ligand（sFasL） in patients with different degree Alzheimer disease（AD）. Methods A total of 100 AD patients,54 patients with old-age diseases（17 cases of diabetes mellitus,18 cases of hypertension,15 cases of hyperlipemia and 4 cases of other endocrine diseases） and 46 healthy subjects were enrolled as old-age disease control group and healthy control group. Serum concentrations of sFas and sFasL were detected by enzyme-linked immuosorbent assay（ ELISA）. The AD patients＇ cognitive functions were evaluated by Clinical Dementia Rating Scale（ CDR）,mini-mental state examination（MMSE） and Hachinski ischemia score（HIS）. Results The levels of serum sFas and sFasL were significantly higher in AD group than in 2 control groups（ P〈0. 01）. As the disease aggravated,the serum levels of sFas and sFasL increased gradually. Serum sFas level was positively correlated with age,course of disease and the scores of MMSE,while it was negatively with the scores of HIS（ r = 0. 856,0. 834,0. 799 and- 0. 714,P〈0. 01）. Serum sFasL level was positively correlated with age and course of disease,while it was negatively with the scores of MMSE and HIS（ r =0. 863,0. 857,- 0. 801 and- 0. 745,P〈0. 01）. Conclusions The abnormal levels of sFas and sFasL among AD patients may indicate being involved in the apoptosis pathological change,and the serum levels of sFas and sFasL might be related with the intelligent level and severity of cerebral ischemia.

关 键 词：可溶性FAS 可溶性FAS配体 阿尔茨海默病 量表 

分 类 号：R446.1[医药卫生—诊断学]