法舒地尔联合α-硫辛酸治疗2型糖尿病伴有勃起功能障碍患者的临床价值研究  

The clinic value of Fasudil combined with alpha lipoic acid in treatment of type-2 diabetes patients with impotence

作　　者：刘毅[1] 张旋[2] 李虎宜[1] 张栩亮[1] 权伟合[1] 

机构地区：[1]湖北医药学院附属东风总医院泌尿外科,湖北十堰442008 [2]湖北医药学院附属东风总医院妇产科,湖北十堰442008

出　　处：《中国性科学》2015年第6期19-21,共3页Chinese Journal of Human Sexuality

基　　金：湖北省教育厅科研计划项目(B20122426)

摘　　要：目的:探讨法舒地尔联合α-硫辛酸治疗2型糖尿病性勃起功能障碍(DMED)的临床价值。方法:连续选择2013年6月至2014年4月入我院内分泌科诊断为DMED患者共76例,平均年龄(46.7±7.2)岁,平均糖尿病病程(6.2±2.8)年,平均体质量指数(25.4±1.3)kg/m2。将其随机分入观察组40例和对照组36例,均予血糖控制治疗。观察组给予盐酸法舒地尔60mg、α-硫辛酸600mg分别加入250m L生理盐水中静滴,1次/d,疗程4周;对照组给予他达拉非5mg口服,1次/晚,4至6周为1个疗程。结果:研究无脱落病例,观察组治疗有效率明显高于对照组(95.0%vs.80.5%,P<0.05);治疗后观察组IIEF-5、EHGS评分及肱动脉FMD值均显著高于对照组(P<0.05);观察组不良反应发生率明显低于对照组(7.5%vs.13.9%,P<0.05)。结论:法舒地尔联合α-硫辛酸可通过改善DMED患者血管内皮功能、勃起硬度达到治疗勃起障碍的目的,且少不良反应,安全性好。Objectives： To study the effect of Fasudil combined with alpha lipoic acid in treatment of type 2 diabetes patients with impotence. Methods： A total of 76 patients diagnosed as type -2 diabetes with impotence from June 2013 to April 2014 in our hospital were selected. The mean age was （46.7 ±7.2） years; the mean dia- betes course was （6.2± 2.8 ） years and the mean body mass index was （25.4 ± 1.3 ） kg/m2. The 76 patients were divided randomly into experiment group （ n = 40） and control group （ n = 36）, all receiving glucose control. The pa- tients in experiment group received Fasudil 60mg and alpha lipoic acid 600mg ＋ 250mL NS once per day, for 4 weeks. The patients in control group received Tadalafil 5mg. Results： There was no loss of cases, the total efficacy rate in experiment group was significantly higher than that in control group （95.0% vs. 80.5%, P 〈 0.05 ） ; the IIEF-5, EHGS score and brachial artery FMD value in experiment group were significantly higher than these incontrol group （ P 〈 0. 05 ） ; the incidence of complications in experiment group was significantly less than that of control group （7.5% vs. 13.9%, P 〈0.05 ）. Conclusion： Fasudil combined with alpha lipoic acid can greatly improve the treatment effect of patients with type 2 diabetes and impotence.

关 键 词：法舒地尔 Α-硫辛酸 2型糖尿病 勃起功能障碍 

分 类 号：R698[医药卫生—泌尿科学]