克霉唑阴道片治疗复发性假丝酵母菌性阴道炎的疗效评价  

Thetherapeutic effect of clotrimazole vaginal tablet in the treatment of recurrent candida vaginitis

作　　者：钟庆[1] 黄燕萍[1] 陈家英[1] 张晓静[1] 

机构地区：[1]北海市妇幼保健院妇产科,广西北海536000

出　　处：《中国性科学》2015年第6期33-36,共4页Chinese Journal of Human Sexuality

摘　　要：目的:探讨克霉唑阴道片在复发性假丝酵母菌性阴道炎的疗效和安全性。方法:选取2013年2月至2014年2月复发性假丝酵母菌性阴道炎患者90例为研究对象,随机分为治疗组45例和对照组45例,分别给予克霉唑阴道片和达克宁栓治疗,1周为1个疗程,治疗2个疗程,随访半年,观察两组治疗前后的临床症状体征积分、复发率及不良反应。结果:治疗组总有效率80.00%,对照组总有效率66.67%,两组相比,具有统计学差异(P<0.05),经治疗后,治疗组的外阴瘙痒、充血水肿、白带异常症状积分分别为(0.42±0.97)分、(0.58±1.10)分、(0.60±1.07)分,均优于对照组(P<0.05),外阴肿痛的积分无统计学差异,两组复发率分别为11.11%、24.44%,无统计学差异(P>0.05)。结论:克霉唑阴道片在改善复发性假丝酵母菌性阴道炎患者的临床症状方面疗效确切。Objectives： To investigate the efficacy and safety of clotrimazole vaginal tablet in the treatment of recurrent candida vaginitis. Methods： 90 patients with recurrent candida vaginitis, who were treated in the hospital from Feb. 2013 to Feb. 2014, were selected and randomly divided into the control group and the obrvation group, 45 cases in each group. The treatment group was treated with clotrimazle vaginal tablet and the control group was treated with mi- conazole nitrate suppositories. Treatment period of the two groups was 2 weeks, with 6 - months follow - up, to observe the clinical symptoms and signs, recurrence rate and the incidence of advelse reactions of two groups before and after treatment. Results： The total effective rate of treatment group and control group was 80. 00% and 66.67% respectively, with significant difference （ P 〈 0. 05）. After treatment, the scores of the pnn＇itus, hypemmia and edema and unusual leucorrhoea of the treatment group were （0. 42±0. 97）, （0. 58 ± 1.10）, （0. 60 ± 1.07） respectively, which were better than these of control group, with statistically significant difference （P 〈0. 05）. The scores of genital sore had no statistical significance （P 〉0. 05）. The recurrence rates of the two groups were 11.11% and 24.44% respectively, with no statistically significant difference （P 〉0. 05）. Conclusion： The clotrimazole vaginal tablet treatment on recurrent candida vaginitis patients has certain advantages, especially in improving clinical symptoms.

关 键 词：复发性假丝酵母菌性阴道炎 克霉唑阴道片 疗效评价 

分 类 号：R167[医药卫生—公共卫生与预防医学]