Hedgehog信号通路在尖锐湿疣皮损患者中的影响研究  

The influence of hedgehog signaling pathway on genital warts with lesions

作　　者：葛天华[1] 黎超伟[1] 曾州平 苏春志 

机构地区：[1]高州市人民医院皮肤科,广东高州525200

出　　处：《中国性科学》2015年第6期72-75,共4页Chinese Journal of Human Sexuality

摘　　要：目的:探讨Hedgehog信号通路三个关键蛋白Patched-1、Gli-1以及Smo在尖锐湿疣患者发病中的作用。方法:本组共收集56例尖锐湿疣患者、40例尖锐湿疣治疗患者以及20例正常人,应用ELISA、Western以及RT-PCR法检测尖锐湿疣皮损患者、咪喹莫特治疗一个疗程后观测患者及正常人皮肤中Patched-1、Gli-1以及Smo的蛋白及mRNA的表达特点。结果:三组Patched-1、Gli-1以及Smo三个指标ELISA以及Western蛋白、RT-PCR mRNA表达,患者组均明显高于对照组(P<0.05),同时治疗组三个蛋白和mRNA表达略高于正常组。结论:尖锐湿疣皮损表皮中Patched-l、Gli-1以及Smo均处于高表达状态,今后或许可用为检测药物治疗后评价指标。Objectives： To investigate the influence of three proteins, Patched - 1, Gli - 1 and Smo, in the Hedgehog signaling pathway on genital warts patients with lesions. Methods ： ELISA, Western and RT - PCR were used to detect Patched - 1, Gli - 1 and Smo proteins and the expression of mRNA of genital warts patients with the lesions treated with imiquimod. The result was compared with that of normal people. Results： There were 56 cases of genital warts untreated patients, 40 cases of genital warts in treatment group and 20 cases in the control group.The level of three key proteins, Patched - 1, Gli - 1 and Smo of the patient group were significantly higher than these of the normal group as well as the expression of mRNA （ P 〈 0. 05）. Conchmion： Patched - 1, Gli - 1 and Smo of genital warts patients with lesions are in high expression status and perhaps can be applied on drug treatment evaluation in the future.

关 键 词：尖锐湿疣 咪喹莫特乳膏 Patched-1 Gli-1 SMO 

分 类 号：R542.2[医药卫生—心血管疾病]