疏肝通络方治疗糖尿病合并非酒精性脂肪肝临床研究  

Clinical study of diabetes combined with non-alcoholic fatty liver disease with soothing liver for dredging collaterals formula

作　　者：高彦彬[1] 赵文景[2] 周晖[3] 张涛静[3] 彭继升[4] 

机构地区：[1]首都医科大学中医药学院,北京100069 [2]首都医科大学附属北京中医医院 [3]北京中医药大学东方医院 [4]北京中医药大学第三附属医院

出　　处：《现代中医临床》2015年第3期7-10,共4页Modern Chinese Clinical Medicine

摘　　要：目的观察疏肝通络方治疗糖尿病合并非酒精性脂肪肝(NAFLD)的临床疗效。方法将120例糖尿病合并NAFLD的患者随机分为治疗组60例、对照组60例,在控制血糖的基础上,对照组采用健康教育、改变生活方式等措施治疗,治疗组在上述基础上加用疏肝通络方口服。结果治疗组60例中,完全缓解5例(8.33%),显效31例(51.67%),有效17例(28.33%),无效7例(11.67%),总有效率为88.33%;对照组59例中,完全缓解2例(3.39%),显效12例(20.34%),有效16例(27.12%),无效29例(49.15%),总有效率为50.85%。经Ridit分析,U=-5.122,P<0.001,说明治疗组总体疗效优于对照组。2组中医症状积分治疗后较本组治疗前均降低(P<0.01),治疗组较对照组降低更明显(P<0.05),说明治疗组优于对照组。2组ALT,AST,TG,TC,LDL-C治疗后均较本组治疗前均降低(P<0.05,P<0.01),治疗组ALT,AST,TG,TC,LDL-C较对照组降低明显(P<0.05)。BMI治疗组较治疗前降低(P<0.01),对照组治疗前后比较差异无统计学意义(P>0.05)。结论疏肝通络方治疗糖尿病合并NAFLD具有较好的疗效。Objective To observe the curative effect of soothing liver for dredging collaterals formula on diabetes combined with non-alcoholic fatty liver disease （ NAFLD ） .Methods 120 patients suffering diabetes combined with NAFLD were randomly divided into treatment group （ n=60 ） and control group （ n=60） .Based on controlling of blood glucose, health education and changing life style were conducted for the control group, soothing liver for dredging collaterals formula were given to the treatment group. Results In treatment group （ n =60 ） , 5 cases got complete remission （ 8.33%） , 31 cases had significant effect （ 51.67%） , 17 cases showed effective （ 28.33%） , 7 cases were presented as ineffective （11.67%）, the total effective rate was 88.33%; In control group （ n=59）, 2 cases got complete remission （3.39%）, 12 cases had significant effect （20.34%）, 16 cases showed effective （27.12%）, 29 cases were presented as ineffective （49.15%）, the total effective rate was 50.85%. Ridit analyze showed U=-5.122, P〈0.001, which indicated the treatment group was superior to the control group.Symptoms of Chinese medicine in both groups decreased significantly compared that before treatment （P〈0.01）, and treatment group decreased more than control group （P〈0.05）, which indi-cated treatment group was superior to control group.ALT,AST,TG,TC and LDL-C of both groups de-creased significantly compared with that before treatment （P〈0.05,P〈0.01）, and ALT, AST, TG, TC, LDL-C of treatment group decreased more than control group （P〈0.05）.BMI of treatment group was significantly lower than that before treatment （P〈0.01）, while in control group, BMI showed no significant differences before and after treatment （P〉0.05）.Conclusions Soothing liver for dredging collaterals formula has good effect on diabetes combined with non-alcoholic fatty liver disease.

关 键 词：疏肝通络方 糖尿病 非酒精性脂肪肝 

分 类 号：R255.4[医药卫生—中医内科学]