糖脂平对代谢综合征患者胰岛素敏感性及炎症因子的影响  

The effect of Tangzhiping on insulin sensitivity and inflammatory factors in patients with metabolic syndrome

作　　者：周晖[1] 高彦彬[2] 

机构地区：[1]北京中医药大学东方医院,北京100078 [2]首都医科大学中医药学院

出　　处：《现代中医临床》2015年第3期11-14,共4页Modern Chinese Clinical Medicine

基　　金：国家中医药管理局资助项目(No.02-03LL02);北京中医药大学自主选题项目(No.2009JYBZZ-JS085)

摘　　要：目的观察糖脂平对代谢综合征(MS)患者胰岛素敏感性及超敏C反应蛋白(hs-CRP)和肿瘤坏死因子α(TNF-α)的影响。方法采用随机平行对照的方法将符合入选标准的70例MS者分为治疗组35例、对照组35例,治疗组在原治疗的基础上给予中药糖脂平汤药口服,对照组在原治疗的基础上给予罗格列酮口服。观察2组治疗前后胰岛素作用指数(IAI)、胰岛素抵抗指数(HOMA-IR)、hs-CRP和TNF-α的变化情况。结果完成临床试验的65例中,治疗组33例,对照组32例。治疗后2组的IAI水平均升高,与本组治疗前比较,差异均有统计学意义(P<0.01);组间比较差异无统计学意义(P>0.05)。治疗后2组的HOMA-IR水平均下降,与本组治疗前比较,差异均有统计学意义(P<0.01);组间比较差异无统计学意义(P>0.05)。治疗前2组的hs-CRP均有轻度升高,治疗后2组的hs-CRP均较本组治疗前明显降低(P<0.01);治疗前后组间比较差异均无统计学意义(P>0.05)。治疗后2组的TNF-α水平均明显降低,与本组治疗前比较,差异均有统计学意义(P<0.01);治疗后组间比较差异无统计学差异(P>0.05)。结论糖脂平可有效改善MS患者的胰岛素敏感性,同时可以降低炎症因子hs-CRP和TNF-α的水平。Objective To observe the effect of Tangzhiping on insulin sensitivity, high sensitive C reactive protein （ hs-CRP ） and tumor necrosis factor-α（ TNF-α） in patients with metabolic syndrome （ MS） .Methods 70 MS patients who met with defined criteria were randomly divided into treatment group （n=35） and control group （n=35）.Besides the original treatment,Tangzhiping and rosiglitazone were given to the treatment group and control group separately for 12 weeks.Insulin action index （ IAI） , insulin resistance index （ IRI ） , hs-CRP and TNF-αwere observed before and after treatment in two groups.Results There were 65 patients fulfilled this trial, among which 33 were treated with Tangzhiping, and 32 were treated with rosiglitazone.IAI were all increased significantly in two groups than those before treatment（P 〈0.01）.There was no statistical significance between two groups（P〉0.05）.IR were all decreased in both groups than those before treatment （ P〈0.01）.There was no statistical significance between two groups（P〉0.05）.The levels of hs-CRP were all higher than the reference value in two groups before treatment.The level of hs-CRP were all decreased in two groups than those before treatment （ P〈0 .01 ） , but there was no statistical significance between two groups （ P〉0.05）.The level of TNF-αwere all decreased in two groups than those before treatment （P〈0.01）, but there was no statistical significance between two groups（ P 〉0.05）.Conclusions Tangzhiping could improve insulin sensitivity of patient with MS.It could also decrease the levels of hs-CRP and TNF-α.

关 键 词：代谢综合征 糖脂平 胰岛素敏感性 炎症因子 

分 类 号：R25[医药卫生—中医内科学]