温阳祛风活血法治疗早期糖尿病周围血管病变的临床研究  

Clinical study of early diabetic peripheral vascular disease with warming yang,expelling pathogenic wind and activating blood circulation

作　　者：王立强 李赫楠 吕小刚 胡连军 曹钋[2] 

机构地区：[1]河北省香河县中医医院内三科,河北065400 [2]北京中医药大学东直门医院

出　　处：《现代中医临床》2015年第3期29-32,共4页Modern Chinese Clinical Medicine

基　　金：河北省中医药管理局科研计划重点课题(No.2013297)

摘　　要：目的观察温阳祛风活血法治疗早期糖尿病周围血管病变的临床疗效。方法将120例早期糖尿病周围血管病变患者随机分为治疗组60例、对照组60例。治疗过程中脱落2例。2组均采取控制血糖、血压等基础治疗。治疗组加用口服祛风活血中药汤剂、外用温阳活血中药汤剂。对照组加服己酮可可碱肠溶片。观察2组临床疗效,2组踝肱指数(ABI)及足背动脉血流量。结果治疗组59例中,显效11例(18.6%),有效37例(62.7%),无效11例(18.6%),总有效率为81.4%;对照组59例中,显效9例(15.3%),有效28例(47.5%),无效22例(37.3%),总有效率为62.7%。经Ridit分析,U=-2.198,P=0.039,P<0.05,说明治疗组临床疗效优于对照组。2组ABI治疗后较本组治疗前均增加(P<0.05),治疗组前后差值较对照组增加明显(P<0.01),治疗组优于对照组。足背动脉血流量治疗组治疗后较本组治疗前增加(P<0.01),对照组治疗前后差异无统计学意义(P>0.05),治疗组前后差值较对照组增加明显(P<0.01),治疗组优于对照组。结论温阳祛风活血法内外同治,对早期糖尿病周围血管病变有较好的临床疗效。Objective To observe the effect of early diabetic peripheral vascular disease with warming yang, expelling pathogenic wind and activating blood circulation.Methods 120 patients with early diabetic peripheral vascular disease were divided into treatment group （ n=60 ） and control group （ n=60 ） , there were 2 expulsion cases in this study.Regular treatments were given to both groups to control the blood glucose and blood pressure.Besides, oral administration of dispelling pathogenic wind for activating blood circulation herbs were taken by treatment group, as well as external use of warming yang for blood circulation herbs.Pentoxifylline was given to the control group.Ankle brachial pressure index （ ABI） and blood flow volume of dorsalispedis artery were recorded.Results In treatment group （ n=59）, 11 cases had significant effect （18.6%）, 37 cases showed effective （62.7%）, 11 cases were presented as ineffective （ 18 .6%） , the total effective rate was 81 .4%; In control group （ n=59 ） , 9 cases had significant effect （15.3%）, 28 cases showed effective （47.5%）, 22 cases were presented as ineffective （37.3%）, the total effective rate was 62.7%; Ridit analyzes showed U=-2.198, P=0.039（ P〈0.05 ） , which indicated treatment group was superior to control group.ABI of both groups improved significantly than those before treatment（P〈0.05）, the differentials of treatment group was＆amp;nbsp;significantly higher than control group （ P〈0 .01 ） , the treatment group was superior to control group. Blood flow volume ofdorsalispedis artery of treatment group increased significantly than that before treatment （ P 〈0.01 ） , while there was no statistical significance in control group （ P 〉0.05 ） . Significant differences of clinical effect were showed in the internal and external development group and pentoxifylline treatment group （ P〈0 .05 ） .the differentials of treatment group was significantly higher than control group （ P〈0.01 ） , the trea

关 键 词：糖尿病周围血管病变 温阳祛风活血法 己酮可可碱 

分 类 号：R255.4[医药卫生—中医内科学]