联合检测血清γ-谷氨酰转肽酶、碱性磷酸酶、超敏C反应蛋白在高龄股骨粗隆骨折患者中的临床意义  

Clinical significance of combined serumγ-glutamyl endopeptidase,alkaline phosphatase with hs-CRP in aged patients with intertrochanteric fracture

作　　者：王信颖[1] 虞陆超 金东旭[1] 张长青[1] 

机构地区：[1]上海交通大学附属第六人民医院骨科,上海200233

出　　处：《中国实验诊断学》2015年第6期894-896,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨血清γ-谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、超敏C反应蛋白(hs-CRP)在高龄股骨粗隆骨折患者中的变化及临床意义。方法 102例内固定手术治疗的高龄股骨粗隆间骨折患者纳入观察组,选择40例非骨折体检老年者纳入对照组,比较两组血清GGT、ALP及hs-CRP水平,并比较不同预后患者血清GGT、ALP及hsCRP水平。结果观察组血清GGT、ALP及hs-CRP水平明显高于对照组,差异有统计学意义(P<0.05);随访12月后,死亡患者22例,存活80例患者中有34例发生各类并发症,其中死亡组及并发症患者血清GGT、ALP及hs-CRP水平均明显高于存活组及无并发症组,差异均有统计学意义(P<0.05)。结论高龄股骨粗隆骨折患者的血清GGT、ALP及hs-CRP均明显升高,且检测水平血清GGT、ALP及hs-CRP水平对于预测高龄股骨粗隆骨折的预后具有重要意义。Objective To investigate of clinical significance of combined serumγ-glutamyl endopeptidase（GGT）,alkaline phosphatase（ALP）with hs-CRP in aged patients with intertrochanteric fracture.Methods 102 aged patients with intertrochanteric fracture were included into the observation group,40 elderly people without fracture examination were included into the control group,the serum GGT,ALP and hs-CRP levels were compared,and those with different prognosis were compared.Results The serum GGT,ALP and hs-CRP levels in observation group were significantly higher than the control group（P〈0.05）;after follow-up of 12 months,there were of 22 patients died,34 patients with complications in 80 patients survived,serum GGT,ALP and hs-CRP levels in death group and complication group were significantly higher than the survival group and non-complication group,the differences were of statistically significant（P〈0.05）.Conclusion The serum GGT,ALP and hs-CRP in aged patients with intertrochanteric fracture were significantly higher,and the detection of these indicators is of great significance in predicting prognosis.

关 键 词：股骨粗隆骨折 骨质疏松 氧化应激 

分 类 号：R687.3[医药卫生—骨科学]