冠心病伴2型糖尿病患者血清中Gas6水平检测及意义  

The clinical significance of Gas6 in conronary heart disease complicated with type 2 diabetes mellitus

作　　者：陈馨[1] 陈杰[1] 蒋冰[1] 徐升强[1] 

机构地区：[1]武汉市第一医院检验科,湖北武汉430022

出　　处：《中国实验诊断学》2015年第6期896-899,共4页Chinese Journal of Laboratory Diagnosis

基　　金：国家自然科学基金资助项目(81170035);武汉市卫生局科研课题(WX12C29);武汉市卫生局科研课题(WX14D02)

摘　　要：目的探讨生长停滞特异性基因产物6(Gas 6)与冠心病伴2型糖尿病患者血清中的变化及其临床意义。方法选择心血管内科120例冠心病患者(CHD)作为冠心病组,120例冠心病伴2型糖尿病患者(CHD+T2DM)组,同时选择健康体检者80例作为对照组。ELISA法对三组血清进行Gas 6的浓度检测,并检测其空腹血糖(FBG)、糖化血红蛋白(HbAlc)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、hs-CRP、同型半胱氨酸(Hcy)含量,并对结果数据进行统计学分析。结果 ELISE法检测健康对照组Gas 6的含量为227.61±7.28pg/ml,冠心病患者组血清中Gas 6含量为278.57±6.61pg/ml,冠心病伴2型糖尿病患者血清中Gas 6含量为285.66±6.37pg/ml。冠心病患者组和冠心病伴2型糖尿病患者组较健康对照组明显升高,冠心病伴2型糖尿病患者组明显高于冠心病患者组,差异有统计学意义(P<0.05)。冠脉狭窄支数越多,血清Gas 6水平越高(P<0.05)。结论生长停滞特异性基因产物6(Gas 6)在冠心病伴2型糖尿病患者血清中浓度明显升高,且随冠脉狭窄支数增多而增高,提示Gas 6参与冠心病伴2型糖尿病的发生发展。Objective To study the change of growth arrest-specific gene 6（Gas 6）in serum of coronary heart disease combined with type 2diabetes mellitus,and clinical significance.Methods We have selected 120 cases of patients with coronary heartdisease（CHD）out of the in-part patients in cardiovascular department as the coronary heart disease group,and 120 cases of patients with coronary heart disease combined with type 2diabetes mellitus（CHD＋T2DM）as coronary heart disease combined with type 2diabetes mellitus group,80 healthy people were selected as controls.Serum levels of Gas6 were determined by an enzyme-linked immunosorbent assay（ELISA）kit,FBG,HbAlc,triglyceride（TG）,high density lipoprotein（HDL）,low density lipoprotein（LDL）,hs-CRP,homocysteine（Hcy）were detected and the data were statistically analyzed.Results ELISA adopted to detect the content of Gas 6in the healthy group was227.61±3.28pg/ml,in CHD group was 278.57±1.61pg/ml and in CHD＋T2DM group was 285.66±2.37pg/ml,in CHD group and CHD＋T2DM group are significantly higher than the control group,CHD＋T2DM group are significantly higher than the CHD group,and the data has statistically significant（P〈0.05）.The more the amount of coronary stenosis is,the higher level of Gas 6is（P〈0.05）.Conclusion The concentraction of growth arrest-specific gene 6（Gas 6）in serum of coronary heart disease combined with type 2diabetes mellitus increased evidently and rise with the increase in the number of coronary stenosis,Gas 6reaction was closely associated with coronary heart disease combined with type 2diabetes mellitus.

关 键 词：生长停滞特异性基因产物6 冠心病 2型糖尿病 炎症因子 

分 类 号：R541.4[医药卫生—心血管疾病] R587.1[医药卫生—内科学]