慢性肾脏病与幽门螺杆菌感染的相关性研究  

The relationship between Helicobacter pylori infection and chronic kidney disease

作　　者：朱进华[1] 丁弘[1] 华召来 朱阳春[3] 田英[1] 宋磊[1] 钱同胜 徐丽[1] 

机构地区：[1]扬中市人民医院肾内科,江苏扬中212200 [2]扬中市肿瘤研究所,江苏扬中212200 [3]扬中市人民医院消化内科 [4]扬中市人民医院检验科,江苏扬中212200

出　　处：《中国实验诊断学》2015年第6期964-968,共5页Chinese Journal of Laboratory Diagnosis

基　　金：江苏省镇江市科技项目(FZ2010013)

摘　　要：目的了解扬中市成人慢性肾脏病（CKD）患病率及幽门螺杆菌（Helicobacter pylori,Hp）感染现状,并探讨Hp感染与CKD的关系,为临床诊疗提供相关依据。方法选择扬中市30-60岁自然人群850名,进行CKD影响因素的问卷调查和CKD相关检测,并行尿素[^13 C]呼气试验检测Hp感染。结果 686名资料完整的参与者中,CKD患病率为26.82%,Hp感染率为61.22%,CKD组Hp感染率为78.26%,非CKD组Hp感染率为54.98%,多因素Logistic回归分析显示,Hp感染、女性、糖尿病、甘油三酯与CKD密切相关。结论江苏省扬中市成人CKD的患病率和Hp感染率均较高,Hp感染是CKD的独立危险因素,Hp感染可能在CKD的发生中起一定作用,扬中市加强Hp感染的筛查及治疗可能对CKD防治工作起重要作用,建议将尿素[^13 C]呼气试验作为CKD患者继发因素的筛查方法之一。Objective To investigate the morbidity of adult chronic kidney disease（CKD）and the prevalence of Helicobacter pylori（Hp）infection in Yangzhong city,and explore the relationship between Hp infection and CKD for clinical diagnosis and treatment.Methods A random sample of 850 adults of 30-60years old in Yangzhong city were recruited.The influence factors of CKD were evaluated by questionnaire and CKD was diagnosed by corresponded detection.Hp infection was made clear throngh ^13 C-ura breath test.Results Within 686 participants with complete datas,the morbidity of CKD was 26.82%,and the HP infection rate was 61.22%.In CKD group,the HP infection rate was 78.26%,as was 54.98%in non-CKD group.Multiple stepwise linear regression analysis demonstrated that Hp infection,female,diabetes mellitus and hypertriglyceridemia were significantly independently associated with CKD.ConclusionThe morbidity of adult CKD and Hp infection rate is higher in Yangzhong city,Jiangsu province.HP infecion was independently associated with CKD and may play a certain role in the development of CKD.It is important for prevention of CKD to strengthen the screening and treatment of Hp infection in Yangzhong city.It is recommended that 13 C-ura breath test should be taken as one of screening methods for the secondary factors of CKD.

关 键 词：肾脏疾病 慢性 患病率 幽门螺杆菌 感染 

分 类 号：R692[医药卫生—泌尿科学]