基质金属蛋白酶-9/基质金属蛋白酶抑制物-1比值与急性冠脉综合征  

Changes of MMP-9 / TIMP-1 ratio in patients with acute coronary syndrom

作　　者：胡茜[1] 石增刚[1] 桑更生[1] 赵卓[1] 年楠 

机构地区：[1]安徽省蚌埠市第三人民医院心内科,233000

出　　处：《淮海医药》2015年第4期325-327,共3页Journal of Huaihai Medicine

摘　　要：目的检测基质金属蛋白酶-9(MMP-9)/基质金属蛋白酶抑制物-1(TIMP-1)比值在急性冠脉综合征(ACS)中的变化。方法 26例非冠心病患者作为对照组;22例稳定性心绞痛(SA组);ACS组40例[包括不稳定性心绞痛(UA)20例,急性心肌梗死(AMI)20例]。通过ELISA方法定量检测外周血基质金属蛋白酶-9(MMP-9),基质金属蛋白酶抑制物-1(TIMP-1),比较MMP-9/TIMP-1比值与冠脉病变的相关性。结果 MMP-9/TIMP-1比值在ACS(3.31±0.72)中显著高于SA(1.97±0.54 P<0.01)及对照组(1.67±0.10 P<0.01)。结论 MMP-9/TIMP-1比值可能成为ACS的新的生物学标记物;MMP-9/TIMP-1比值的增高可能反应了斑块的不稳定性,对不稳定斑块的检出、冠心病的危险度分层有一定的意义。Objective To investigate the variety of matrix metalloproteinase-9 （ MMP-9 ）/ tissue inhibitor of metalloptein- ase-1 { TIMP-1 ） ratio in patients with acute coronary syndrome （ ACS）. Methods 26 controls and 22 cases with stable angina （SA） ,40 cases with ACS including 20 with unstable angina （ UA ） , 20 with acute myocardial infarction （AMI） were studied. Serum MMP-9 and TIMP-1 levels were determined by ELISA. The relation between MMP-9/TIMP-1 ratio changes and coronary artery lesion was investigated. Results Patients with ACS showed a significant increase of MMP-9/TIMP-1 ratio （ 3.31 ± 0.72） compared with those in SA （ 1. 97 ± 0. 54 P 〈 0. 01} and controls （1. 67 ± 0.10 P 〈 0. 01） . Conclusion MMP-9/ TIMP-1 ratio may serve as a new biomarker for detection of ACS. The changes of MMP-9/TIMP-1 ratio may reveal the instabili- ty of coronary atherosclerotic plaque and contribute to the detection of instability plaque and risk stratification in coronary heart disease （ CHD ）.

关 键 词：急性冠脉综合征 基质金属蛋白酶-9 基质金属蛋白酶抑制物-1 复杂性狭窄 

分 类 号：R543.3[医药卫生—心血管疾病]