骨桥蛋白对诊断左心室射血分数保留性心力衰竭的临床价值  

Value of osteopontin in diagnosis of heart failure with preserved ejection fraction

作　　者：周文杰[1] 

机构地区：[1]如皋市人民医院心内科,如皋226500

出　　处：《山西医科大学学报》2015年第6期510-512,共3页Journal of Shanxi Medical University

摘　　要：目的探讨骨桥蛋白对诊断左心室射血分数保留性心力衰竭(HFPEF)的临床价值。方法收集被确诊为HFPEF患者59例,同时募集了54例正常人作为对照组,抽取两组患者的空腹静脉血,然后使用酶联免疫法检测两组患者的骨桥蛋白(OPN)和脑钠肽(BNP)的含量,最后比较两组患者间的OPN和BNP的差异,分析OPN和BNP之间的相关性,同时ROC曲线分析OPN和BNP对诊断HFPEF的特异性和灵敏度。结果两组患者OPN和BNP水平均存在显著的差异(P<0.01),心衰组OPN和BNP水平大于正常对照组,OPN和BNP在两组中均存在相关性(心衰组:r=0.679,P<0.01;对照组:r=0.594,P<0.01)。OPN对心衰诊断的灵敏度74.6%、特异性72.7%,而BNP灵敏度69.5%、特异性62.9%。结论 OPN在发生了HFPEF后其值显著升高,对HFPEF的诊断具有较高的临床价值,与BNP对HFPEF的诊断作用类似,甚至效果更优。Objective To explore the clinical value of osteopontin for diagnosing the heart failure with preserved ejection fraction（ HF- PEF）. Methods Fifty-nine patients diagnosed as heart failure with preserved ejection fraction were collected, and 54 healthy sub- jects were recruited as control group. The venous blood was collected to detect the levels of OPN and BNP by ELISA. The relationship between OPN and BNP was analyzed. The ROC curve was used to analyze the sensitivity and specificity of OPN and BNP to HFPEF. Results The levels of OPN and BNP in HEPEF group were significantly higher than in control group （ P 〈 0.01 ）. OPN was correlated with BNP in two groups （ HEPEF group： r = 0.679, P 〈 0.01 ; control group ： r = 0.594, P 〈 0.01 ）. The sensitivity and specificity of OPN to HFPEF were 74.6% and 72.7%, respectively. The sensitivity and specificity of BNP to HFPEF were 69.5% and 62.9% , re- spectively. Conclusion OPN increases after HFPEF. OPN is helpful to diagnose the HFPEF and even superior to BNP.

关 键 词：骨桥蛋白 左心室射血分数保留性心力衰竭 脑钠肽 

分 类 号：R541.6[医药卫生—心血管疾病]