前列地尔治疗老年戊型淤胆型肝炎的疗效观察  

THE CURATIVE EFFECT OF? ALPROSTADIL ON SENILE CHOLESTATIC HEPATITIS E

作　　者：范冬梅 

机构地区：[1]兰陵县人民医院感染科,山东兰陵277700

出　　处：《山东医学高等专科学校学报》2015年第2期97-99,共3页Journal of Shandong Medical College

摘　　要：目的探索前列地尔治疗老年戊型淤胆型肝炎的临床疗效。方法 70例老年戊型淤胆型肝炎患者随机分为观察组和对照组各35例。对照组给予甘草酸二胺、门冬氨酸钾镁、还原型谷胱甘肽等一般护肝治疗,治疗组在对照组治疗的基础上加用前列地尔10ug加入生理盐水100ml中静脉滴注,每日1次,两组疗程均为4周,比较肝功能指标和临床疗效。结果治疗4周后治疗组总胆红素(TBil)、谷丙转氨酶(ALT)、谷草转氨酶(AST)均较对照组明显下降(P<0.01),且总有效率优于对照组(P<0.05)。结论前列地尔联合保肝药物治疗老年戊型淤胆型肝炎疗效肯定,且无不良反应。Objective To observe the curative effect of ？alprostadil on？senile？cholestatic hepatitis E . Methods 70 cases of senile cholestatic hepatitis E were randomly divided into two groups .The control group was given diammonium glycyrrhizinate ,potassium magnesium aspartate and reduced glutathione , while the treatment group was given 10ug of alprostadil？and 100ml of normal saline ,once a day ,in addi-tion to the therapy used for the control group ,four weeks as a course in both groups .The liver function indexes and the clinical effect in both groups were compared .Results The content of total bilirubin ,alanine transaminase and glutamic oxalacetic transaminase decreased more obviously in the treatment group than in the control group （ P 〈0 .01） ,and the total effective rate was higher in the treatment group than in the control group （ P 〈 0 .05） .Conclusion Alprostadil and hepatoprotective drug can produce good curative effects on senile cholestatic hepatitis E without causing any side effects .

关 键 词：前列地尔 淤胆型肝炎 戊肝 

分 类 号：R512.65[医药卫生—内科学]