体外受精-胚胎移植周期中注射绒毛膜促性腺激素日血清性激素水平及卵泡大小与妊娠结局相关性的研究  

RELATIONSHIP BETWEEN THE PREGNANCY RATE AND SEX HORMONE AND FOLLICLE SIZE OF INFERTILITY WOMEN UNDERGOINGIVF-ET

作　　者：从兰香[1] 孙永[1] 

机构地区：[1]临沂市人民医院生殖医学科,山东临沂276003

出　　处：《山东医学高等专科学校学报》2015年第2期119-122,共4页Journal of Shandong Medical College

基　　金：临沂市2012年科技发展计划项目(No.201213029)

摘　　要：目的探讨体外受精-胚胎移植(IVF-ET)血清性激素水平和卵泡大小与临床妊娠率的关系。方法对156例(160个周期)行IVF-ET助孕的不孕患者的临床资料进行回顾性分析,采用多因素非条件逐步Logistic回归方法分析注射绒毛膜促性腺激素(hCG)日血清雌二醇(E2)浓度、孕激素(P)浓度、促黄体生成素(LH)浓度和主导卵泡大小与IVF-ET临床妊娠结局的关系。结果注射hCG日血清E2≥5000pg/ml(OR=0.4662),P≥1.5ng/ml(OR=0.3783),LH≥10mIU/ml(OR=0.2564)是妊娠率降低的因素(P均<0.05);hCG注射日主导卵泡≥18mm且≤25mm(OR=1.2586)是妊娠率提高的因素(P<0.05)。结论 IVF-ET临床妊娠率受hCG日血清E2、P、LH浓度和主导卵泡大小多因素的影响。Objective To explore the relationship between the pregnancy rate and sex hormone and follicle size of infertility women undergoing in vitro fer-tilization and embryo transfer （IVF-ET ） .Methods The clinical data of 156 infertility women undergoing IVF-ET were retrospectively analyzed .Multiple-factor non-conditional Logistic regression was used to analyze the levels of estradiol （E2） ,progesterone （P） and luteinizing hormone （LH） on the day chorionic gonadotro-pin （hCG） was injected and to explore the relationship between the pregnancy rate and sex hormone and follicle size of infertility women undergoing IVF-ET .Results E2≥5000pg/ml（OR=0 .4662） ,P ≥1 .5ng/ml（OR=0 .3783） ,and LH≥10 mIU/ml（OR=0 .2564） ,which led to the reduction of pregnancy rate（ P〈0 .05） .When the leading follicle size was equal to or between 18mm and 25mm （OR =1 .2586） ,the pregnancy rate rose significantly（ P 〈0 .05） .Conclusion The pregnancy rate when chorionic gonadotropin （hCG） is injected is mainly affected by the levels of E2 ,P and LH as well as the follicle size .

关 键 词：体外受精-胚胎移植 妊娠结局 性激素 卵泡 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]