亚洲人群TCF7L2基因rs12255372位点多态性与2型糖尿病关系的Meta分析  

Meta-Analysis on the association of rs12255372 polymorphisms in TCF7L2 gene with the risk of T2DM in Asian population

作　　者：欧阳璐[1] 李剑[1] 吴勤[1] 董明华[1] 李舒梅[1] 

机构地区：[1]赣南医学院,江西赣州341000

出　　处：《赣南医学院学报》2015年第2期202-207,共6页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金资助项目(NO:30860246);江西省科技支撑计划项目(NO:20132BBG70086)

摘　　要：目的:探讨转录因子7类似物2(transcription factor 7 like 2,TCF7L2)基因rs12255372位点多态性与亚洲人群2型糖尿病(T2DM)发病的相关性。方法:通过电子计算机检索国内外有关TCF7L2基因rs12255372与T2DM关系的病例对照或队列研究文献,提取入选文献相关数据并应用Rev Man 5.3软件进行固定效应及随机效应模型Meta分析。结果:筛选到27篇符合要求的文献,包括T2DM病例15 300例,健康人群对照12 693例;异质性检验显示各研究间存在有统计学意义的异质性(Q=57.10,P=0.002);rs12255372位点等位基因(T/G)的分布频率在病例组和对照组之间差异有统计学意义(P<0.000 1),病例组的T等位基因分布频率显著高于对照组,合并OR(95%CI)为1.45(1.32,1.59);发表偏倚分析和敏感性分析结果证实,上述Meta分析结果稳定、可靠。结论:rs12255372位点T等位基因可增加亚洲人群T2DM的发病风险,TT/TG基因型是T2DM的风险基因型。Objective： To evaluate the association of the transcription factor 7-like 2（ TCF7L2） polymorphism rs12255372 with type 2 diabetes mellitus（ T2DM） in Asian population. Methods： Literature of case-control study or cohort study on TCF7L2 rs12255372 polymorphism with T2 DM in Asian population was collected. To do the meta-analysis,the fixedeffects and random-effects model within the Rev Man 5. 3 software was used. Results： Twenty-seven eligible papers（ with15,300 cases and 12,693 controls） were included in the final meta-analysis. The heterogeneity test revealed the significant heterogeneity in the studies（ Q = 57. 10,P = 0. 002）. The rs12255372 T allele was significantly associated with T2DM（ P 〈0. 0001）,considering the T allele itself（ OR = 1. 45,95% CI = 1. 32,1. 59）. Publication bias and sensitivity analysis confirmed the meta-analysis results. Conclusion： It is confirmed that rs12255372 is significantly associated with susceptibility to T2 DM in Asian population,the risk allele and the genotypes will increase the risk of T2 DM.

关 键 词：2型糖尿病 转录因子7类似物2基因 rs12255372 亚洲人群 META分析 

分 类 号：R587.1[医药卫生—内分泌]