检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
出 处:《中华内分泌外科杂志》2015年第3期201-203,226,共4页Chinese Journal of Endocrine Surgery
摘 要:目的:探讨胃旁路术( gastric bypass,GBP)治疗不同体重指数( body mass index,BMI)的2型糖尿病(type 2 diabetes mellitus,T2DM)的临床效果。方法将宝鸡人民医院2012年9月至2013年7月间行手术治疗的T2DM分为2组:肥胖组BMI≥28 kg/m^2)16例,超重组( BMI<28 kg/m^2)21例,均行GBP。观察术后3、6个月患者空腹血糖( FPG)、胰岛素抵抗指数( HOMA-IR)、胰岛素刺激释放( INS)、C肽释放、BMI、糖化血红蛋白(HbA1c)变化。结果术后3个月INS、C肽较术前均好转(P<0.05),术后6个月基本接近正常值;术后3个月HbA1c与术前比较明显下降(P<0.05),术后6个月基本接近正常值;HO-MA-IR与术前比较差异有统计学意义,同时肥胖组差异有统计学意义( P<0.05);术后3个月肥胖组体重较术前明显下降,术后6个月肥胖组体重下降达稳态,BMI<25 kg/m2达到15例(93.7%),差异有统计学意义(P<0.05),超重组体重有所下降,但差异无统计学意义(P>0.05)。肥胖组术后3、6个月血糖均不同程度下降,术后6个月肥胖组有效率92%,超重组有效率78%,2组总有效率90%。结论 GBP对不同BMI的T2DM均有明显治疗价值,但肥胖组显效优于超重组;GBP治疗T2DM疗效有效,值得临床推广。Objective To investigate the clinical effects of gastric bypass( GBP) on type 2 diabetes mel-litus(type 2 diabetes mellitus, T2DM)patients with different body mass index(BMI).Methods T2DM patients undergoing GBP from Sep.2012 to Jul.2013 were divided into 2 groups:obese group( BMI≥28 kg/m2 , 16 ca-ses)and overweight group(BMI〈28 kg/m2,21 cases).Changes of fasting plasma glucose(FPG), insulin resist-ance index(HOMA-IR)and insulin stimulation release(INS), C peptide release, BMI, glycosylated hemoglobin ( HbA1c) at 3 and 6 months after surgery were observed.Results INS and C peptide improved 3 months after surgery(P〈0.05),and they were close to normal at 6 months after surgery.HbA1c significantly decreased 3 months after surgery compared with that before surgery( P〈0.05) and it was close to normal at 6 months after sur-gery.Patients in obese group had significantly declined weight 3 months after surgery compared with that before surgery, and reached the steady state 6 months after surgery.15 cases(93.7%) in the obese group had BMI〈25 kg/m2 , and the difference had statistical significance ( P〈0.05 ) .Patients in the overweight group had their weight declined but no statistical difference was found(P〉0.05).Blood sugar in the obese group decreased with different degrees at 3 and 6 months after surgery.The effective rate was 92%for the obese group and 78%for the overweight group.The overall effective rate was 90%.Conclusion GBP has significant therapeutic value for T2DM patients with different BMI, especially for patients in obese group, which is worth of clinical promotion.
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.222