高甲状腺素心房颤动易患模型对左心房电生理变化的影响研究  

Effect of atrial fibrillation model by high thyroxine on the electrophysiological changes in left atrium

作　　者：郑甲林[1] 郭涛[2] 张新金[1] 陶四明[1] 代华磊[1] 李建美[1] 

机构地区：[1]昆明医科大学第四附属医院心内科,云南昆明650021 [2]昆明医科大学第一附属医院心内科,云南昆明650021

出　　处：《中国生化药物杂志》2015年第4期48-50,54,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨建立兔高甲状腺素心房颤动(房颤)易患模型,并检测左心房电生理指标变化。方法日本大耳兔49只随机分为3组,对照组(10只,每日注射生理盐水)、撤药组(20只,每日注射甲状腺素50μg/kg,2月后撤药改注射等剂量生理盐水)、持续给药组(19只,每日注射甲状腺素50μg/kg),实验时间均为4月。收集各组左心房有效不应期(AERP)、激动传导速度(CV)、激动波长(WL)和房颤诱发率等数据。结果干预2月后撤药组、持续给药组较对照组AERP200、AERP150均缩短(P<0.05),4月后持续给药组较撤药组、对照组AERP200、AERP150明显缩短(P<0.01);干预2月后撤药组、持续给药组较对照组CV减慢(P<0.05),4月后持续给药组较撤药组、对照组CV明显减慢(P<0.01);干预2月后撤药组、持续给药组较对照组WL缩短(P<0.05),4月后持续给药组较撤药组、对照组CV明显缩短(P<0.01);对照组没有诱发出房颤,4月后持续给药组房颤诱发率显著增高,撤药组下降。结论制作高甲状腺素兔房颤易患模型切实可行,并伴有左心房电生理指标改变,为进一步研究甲亢合并房颤发病机制提供动物实验基础。Objective To investigate about establishment the animal model of atrial fibrillation（AF） by high thyroxine and electrophysiological study of left atrium.Methods 49 rabbits were randomly divided into three groups, control group （10, injection of saline）, withdrawal group （20, injection of levo-thyroxine 50μg/kg, change to inject isodose saline after two months）, continuous dosing group （19, injection of levo-thyroxine 50μg/kg everyday）.the data of left atrium effective refractory period（AERP）, conduction velocity（CV）, wavelength（WL） and AF induced ratio were collected after four months.Results The withdrawal group and continuous dosing group AERP200, AERP150 were more shorter than the control group after two months（P〈0.05）, The continuous dosing group AERP200, AERP150 was shorter significantly than withdrawal group and control group after four months （ P〈0.01 ）.The withdrawal group and continuous dosing group CV were slower than control group after two months （ P〈0.05 ）.The continuous dosing group CV was slower significantly than withdrawal group and control group after four months （ P〈0.01 ）.The withdrawal group and continuous dosing group WL were shorter than control group after two months（P〈0.05）, The continuous dosing group WL was shorter significantly than withdrawal group and control group after four months （P〈0.01）.The AF induced ratio in the continuous dosing group increased significantly（P〈0.01）. After four months, but the withdrawal group decreased, the control group did not induce AF.Conclusion It＆#39;s feasible to establish the rabbit model of AF by high thyroxine, with left atrium electrophysiological changes, which provides animal model for further to study the pathogenesis of AF cause of hyperthyroidism.

关 键 词：心房颤动 甲状腺素 兔 动物模型 

分 类 号：R541.7[医药卫生—心血管疾病]