依达拉奉对急性脑梗死患者炎症因子、6-酮-前列腺素F_(1α)、血栓素B2、血管内皮功能、和肽素及N末端脑钠素原的影响  

Effect of edaravone on inflammatory factors 6-keto-prostaglandin F_(1α),thromboxane B2,endothelial function,copeptin and N-terminal brain natriuretic peptide in patients with acute cerebral infarction

作　　者：郭华[1] 陈炅[1] 索冬卫[1] 

机构地区：[1]郑州大学第五附属医院急诊科,河南郑州450052

出　　处：《中国生化药物杂志》2015年第4期77-80,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨依达拉奉对急性脑梗死患者血清炎症因子、6-酮-前列腺素F1α（6-keto-prostaglandin F1α,6-keto-PGF1α）、血栓素B2、血管内皮功能及血清和肽素和N末端脑钠素原（N-terminal brain natriuretic peptide,NT-pro BNP）的影响。方法选择自2013年3月~2014年9月期间郑州大学第五附属医院收治的213例急性脑梗死患者随机分为对照组（n=101）和观察组（n=112）。对照组采用常规对症治疗,观察组在对照组基础上结合依达拉奉注射液治疗。对比分析2组血清炎症因子、6-keto-PGF1α、血栓素B2、血管内皮功能、血清和肽素、NT-pro BNP及神经功能评分和日常生活能力（activities of daily living,ADL）评分。结果观察组治疗后血清C-反应蛋白（C-reactive protein,CRP）、白介素-8（interleukin-8,IL-8）、白介素-10（interleukin-10,IL-10）显著低于对照组（P〈0.05）;观察组治疗后血浆血栓素B2显著低于对照组（P〈0.05）,6-keto-PGF1α显著高于对照组（P〈0.05）;观察组治疗后血清和肽素、NT-pro BNP水平显著低于对照组（P〈0.05）;观察组治疗后血浆内皮素-1（endothelin-1,ET-1）显著低于对照组（P〈0.05）,血浆一氧化氮（nitric oxide,NO）显著高于对照（P〈0.05）;观察组治疗后神经功能评分显著低于对照组（P〈0.05）,ADL评分显著高于对照组（P〈0.05）。结论通过初步研究发现,依达拉奉治疗急性脑梗死机制可能与降低血清炎症因子、增加6-keto-PGF1α和降低血栓素B2、改善血管内皮功能及降低血清和肽素和N末端钠素原相关,具有重要意义。Objective To investigate effect of edaravone on serum inflammatory factors, 6-keto-prostaglandin F1α（6-keto-PGF1α）, thromboxane B2, endothelial function and serum copeptin and N-terminal brain natriuretic peptide （NT-proBNP） in patients with acute cerebral infarction.Methods From March 2013 to September 2014, 213 cases of acute cerebral infarction were selected in the hospital and randomly divided into control group （n=101） and observation group （n =112）.Control group were given conventional symptomatic treatment, and observation group were given edaravone injection on the basis of control group.The serum inflammatory cytokines, 6-keto-PGF1α, thromboxane B2, endothelial function, serum copeptin, NT-proBNP and nerve function score and activities of daily living （ ADL） score were compared between two groups.Results Serum CRP, IL-8, IL-10 in observation group after treatment were significantly lower than control group （P〈0.05）.Plasma thromboxane B2 in observation group after treatment was significantly lower than control group （P〈0.05）.The levels of 6-keto-PGF1αwas significantly higher than control group （P〈0.05）.Serum copeptin and NT-proBNP levels in observation group after treatment were significantly lower than control group （P〈0.05）.Plasma ET-1 in observation group after treatment was significantly lower than control group （ P〈0.05 ） , and plasma NO was significantly higher than the control （ P〈0.05 ）.Neurological function in observation group after treatment was significantly lower than control group （P〈0.05）, and ADL score was significantly higher （P〈0.05）. Conclusion The preliminary study shows that edaravone in treatment of acute cerebral infarction may be associated with decreasing serum inflammatory cytokines, increasing 6-keto-PGF1αand reducing thromboxane B2, improving endothelial function and reducing serum copeptin and N-terminal natriuretic peptide.

关 键 词：依达拉奉 急性脑梗死 炎症因子 6-酮-前列腺素F1α 血栓素B2 血管内皮功能 和肽素 N末端脑钠素原 

分 类 号：R798.7[医药卫生—临床医学]