纳米级铅对小鼠免疫球蛋白和T淋巴细胞亚型影响的研究  

Effect of nanometer-Pb on the serum immunoglobulin contents and T lymphocyte subsets in mice

作　　者：周勇[1] 刘瑜[1] 何军山[1] 张红梅[2] 

机构地区：[1]湘南学院预防医学系,湖南郴州423000 [2]郴州市疾病预防控制中心

出　　处：《实用预防医学》2015年第7期781-783,共3页Practical Preventive Medicine

基　　金：湖南省重点学科"流行病与卫生统计学"建设项目;郴州市科技计划项目(项目编号:CZ2013091)

摘　　要：目的探讨纳米级铅对小鼠免疫球蛋白和T淋巴细胞亚型的影响。方法将健康昆明种小白鼠80只随机分为5组,通过灌胃摄入不同剂量的纳米级二氧化铅和普通二氧化铅,连续5d后测定免疫球蛋白含量和T淋巴细胞亚群。结果不同剂量的纳米级二氧化铅均可导致小鼠血清免疫球蛋白IgG、IgM、IgE含量下降,CD4+T淋巴细胞亚群减少,CD4+/CD8+T淋巴细胞的比值下降(P<0.05),其中高剂量纳米级铅组小鼠的各项免疫指标下降最为明显。相同剂量时,纳米级铅染毒组的免疫指标值相对于普通铅染毒组要低(P<0.05)。结论纳米级铅可对小鼠的免疫功能产生损害,并且其的损害作用大于普通PbO2。Objective To explore the impact of nanometer-Pb on the serum immunoglobulin and T lymphocyte subsets in mice. Methods Eighty healthy Kunming mice were randomly divided into 5 groups, including low - dose, middle- dose and high - dose nano- PbO2 groups, the common PbO2 group and the control group. The mice of the 3 nano- PbO2 groups received different doses of nano- PbCh by garage for 5 successive days, and then the serum irnmunoglobulin contents and T lymphocyte subsets were measured. Results The levels of serum IgG, IgM and IgE, the percentage of CD4 ＋ T lymphocyte and the ratio of CD4＋/CD8＋ T lymphocyte of mice in the 3 nano - PbO2 groups all declined （P〈0.05）, of which the immune indexes of mice in the high- dose nano - PbO2 group declined the most. At the same experimental dose, the serum levels of immune indexes of mice in the nano - PbO2 groups were lower than those in the common PbO2 group （P 〈 0.05）. Conclusions Nanometer - Pb can damage the immune function of mice, and the adverse effects induced by nano- PbO2 are distinctly stronger than those by the common PbO2.

关 键 词：纳米级铅 免疫球蛋白 T淋巴细胞亚型 

分 类 号：R332[医药卫生—人体生理学]