老鼠簕叶化学成分及其抗流感病毒活性  

Chemical Constituents from Leaves of Acanthus ilicifolius and Their Anti-influenza Virus Activities

作　　者：陈艳萍[1,2] 谭道鹏 曾琪[1] 王宇 严启新 曾令杰[1] 

机构地区：[1]广东药学院中药学院,广东广州510006 [2]深圳海王药业有限公司,广东深圳518057

出　　处：《中药材》2015年第3期527-530,共4页Journal of Chinese Medicinal Materials

基　　金：深圳市海洋药物工程中心基金(深发改【2011】1673号)

摘　　要：目的：研究老鼠簕叶的化学成分。方法：采用硅胶和凝胶柱色谱进行分离纯化,根据理化性质和波谱数据鉴定化合物结构。采用检测流感病毒神经氨酸酶活性测定所分离得到化合物的抗流感病毒活性。结果：从老鼠簕叶中分离得到5个化合物,分别鉴定为：blepharin（1）、麦角甾苷（2）、异类叶升麻苷（3）、胡萝卜苷（4）、豆甾醇-3-O-β-D-葡萄糖苷（5）。结论：以上化合物均为首次从该植物叶中分离得到,化合物1-3具有一定的抗流感病毒活性。Objective：To study the chemical constituents from the leaves of Acanthus ilicifolius. Methods ：The compounds were isolated by silica and gel column chromatographic methods and identified by spectroscopic analysis. The anti-influenza virus activities of these compounds were obtained by measuring the neuraminidase activity of influenza virus. Results：Five compounds were isolated and their structures were identified as blepharin（ 1 ） , acteoside （2） , isoverbascoside （ 3 ）, daucosterol （ 4 ）, and 3-O-β-D-glucopyranosyl-stig- masterol（5 ）. Conclusion ：All the compounds are isolated from the leaves of Acanthus ilicifolius for the first time, and compounds 1 -3 exhibit the anti-influenza virus activities.

关 键 词：老鼠簕 化学成分 苯乙醇苷 抗流感病毒 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]