听觉P300对认知损害的评定作用与康复过程中的动态观察  

The Assessment and Dynamic Observation in Rehabilitation Course on the Auditory P300 on Patients with Cognitive Impairment

作　　者：罗跃嘉[1] 吴宗耀[1] 

机构地区：[1]第三军医大学西南医院康复理疗科

出　　处：《中国康复》1991年第2期58-62,共5页Chinese Journal of Rehabilitation

摘　　要：对102例大脑疾病患者测听觉P300,痴呆的P300潜伏期比年龄匹配的正常人和对照者分别延长77.17与60.10mS,波幅显著性降低。潜伏期与MMSE分呈显著性负相关,波幅与之呈显著性正相关。以P300潜伏期超过其年龄匹配的正常预期值2SD作为评定认知损害的阳性标准,P300测定与MMSE的符合率达90％。对31例病人的P300动态观察表明认知功能改善,MMSE分增加,P300潜伏期缩短;功能衰竭,MMSE分降低,潜伏期延长。研究认为P300测定对认知损害有客观,定量的评价作用,可用于临床诊断与康复疗效评定。Auditory P300 were recorded from 102 cognitive impaired patients with cognitive impairment due to cerebropathies. The mean latency of the P300 for the dementia patients was 77.17ms (3.84 SD) longer than that for the age-matched normal subjects and 60.10ms (3.22 SD) longer than that for the control. The amplitude for the dementia patients was lower than that for the normal and control. The negative correlation between the P300 latency and MMSE Scores was significant and the correlation between the amplitude and MMSE was positive. The value of latency of the P300 longer than the expected value for age-matched normal subjects by LSP can be taken as diagnostic criterion for the cognitive impairment. This was in agreement with what was found by MMSE in 90％ cases. Results obtained by sequential test on31 patients showed that decrease in the P300 latency was alwaysassociated with clinical improvement in cognitive function and increase in MMSE score, while prolongation with clinical deterioration and decrease in MMSE score. The author believes that P300 measurent may provide a objective and quantitative index for cognitive impairmet It conld be used for clinical diagnosis and rehabilitation assessment.

关 键 词：听觉P300 痴呆 认识损害 康复 

分 类 号：R493[医药卫生—康复医学]