Facile microwave-assisted synthesis of 1H-pyrazino[1,2-a]quinoxaline-1,5(6H)-dione derivatives via a nucleophilic substitution reaction  

作　　者：Xiaoyan Zhang Guiting Song Hailei Cui Zhigang Xu Jin Zhu Zhongzhu Chen 

机构地区：[1]Key Laboratory of the Ministry of Education for Advanced Catalysis Materials [2]Department of Chemistry and Life Science,Zhejiang Normal University [3]Key Laboratory for Asymmetric Synthesis and Chiral Technology of Sichuan Province [4]Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences [5]University of Chinese Academy of Sciences [6]Drug Discovery Center of Innovation,Chongqing University of Arts and Sciences

出　　处：《Science China Chemistry》2015年第7期1239-1242,共4页中国科学（化学英文版）

基　　金：supported by the Scientific Research Foundation of Chongqing University of Arts and Sciences(R2013XY01,R2013XY02);the Chongqing Science and Technology Commission(CSTC2013JCYJA50028);SRF for ROCS,SEM

摘　　要：A series of compounds containing the 1H-pyrazino[1,2-a]quinoxaline-1,5(6H)-dione scaffold have been synthesized using a one-pot procedure under microwave irradiation. This new strategy allowed for the facile synthesis of target compounds in good yields and could be readily applied to the construction of diverse libraries of compounds for high throughput screening in medicinal chemistry.A series of compounds containing the 1H-pyrazino[1,2-a]quinoxaline-1,5（6H）-dione scaffold have been synthesized using a one-pot procedure under microwave irradiation. This new strategy allowed for the facile synthesis of target compounds in good yields and could be readily applied to the construction of diverse libraries of compounds for high throughput screening in me- dicinal chemistry.

关 键 词：nucleophilic substitution reaction microwave Ugi reaction MCRS 1H-pyrazino[1 2-a]quinoxaline-l 5（6H）-dione 

分 类 号：O621.25[理学—有机化学]