复苏周期单囊胚移植可行性研究  

A feasibility study on single blastocyst transfer in warming cycles

作　　者：刘吉[1] 程东凯[1] 翁宁[1] 许篷 李彩虹[1] 于洪君[1] 孙晓玲[1] 李宝山[1] 

机构地区：[1]沈阳东方医疗集团菁华医院,沈阳110005

出　　处：《中国优生与遗传杂志》2015年第6期99-100,44,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的通过对复苏周期不同年龄段的单囊胚移植和双囊胚移植的妊娠率、种植率及多胎率的统计分析,探索单囊胚移植的可行性。方法以本中心2012年的1367个囊胚复苏周期作为研究对象,将其分为单囊胚移植和双囊胚移植两组,每组按不同年龄分为A组(小于35岁组)、B组(35-38岁组)和C组(大于等于38岁组)。分别对其妊娠率、种植率及多胎率进行比较分析。结果 A组和C组单囊胚移植的妊娠率(51.52%,32.65%)显著低于双囊胚移植(62.73%,50.65%),而B组的单囊胚移植的妊娠率(48.39%)略低于双囊胚移植(56.84%),无显著差异;三个年龄组单囊胚移植率(44.51%,41.94%,24.49%)略高于双囊胚移植的种植率(38.79%,31.05%,22.73%),无显著差异;单囊胚移植的多胎仅发生在A组(2.96%),都显著低于双囊胚移植组(23.34%,29.63%,15.38%),而双囊胚移植的多胎率在B组最高,C组最低,无显著差异。结论冷冻复苏周期,小于38岁的患者可以选择性单囊胚移植,而对于38岁以上的患者建议双囊胚移植。Objective： To compare the pregnancy rate, implantation rate, the rate of multiple births of single blastocyst transfer and double embryo transfer in frozen-thawed cycle, we divided into several groups by different ages, and explore the feasibility of single blastocyst transfer. Methods： We chose 1367 blastocyst frozen-thawed cycle in 2012 as the research obje,.t, which is divided into two groups.One is single blastocyst transfer and the other is double blastocyst transfer, then according to different age, each group were divided into A group （less than 35 years） , group B （35 to 38） and C group （over 38 years） . The pregnancy rate, implantation rate and multiple pregnancy rate were compared and analyzed respectively. Results： The pregnancy rates （51.52%, 32.65% ） of group A and group C single blastocyst transfer were significantly lower than that of double embryo transfer （62.73%, 50.65%） , and pregnancy rate （48.39%） of group B single blastocyst transfer was slightly lower than the double embryo transfer （56.84%） , no significant differences between the three age groups; The implantation rate （44.51%, 41.94%, 24.49%） of single blastocyst transfer is slightly higher than the implantation rate （38.79%, 31.05%, 22.73%） of double blastocyst transfer, no significant difference; multiple pregnancy of single blastocyst transfer occurs only in group A （2.96%） , were significantly lower than the group of double blastocyst transfer （23.34%, 29.63%, 15.38%） , and the highest multiple births rate of double blastocyst transfer is group B, group C was the lowest, with no significant difference. Conclusion- In freezing-thawing cycle, patients less than 38 years old can choose single blastocyst transfer, and for patients more than 38 years is recommended for double embryo transfer.

关 键 词：单囊胚移植 双囊胚移植 妊娠率 种植率 多胎率 

分 类 号：R714.8[医药卫生—妇产科学]