23例芪苈强心胶囊相关洋地黄过量病例分析  

Analysis of 23 cases of Qiliqiangxin Capsules in Relation to Digitalis Overdose

作　　者：李琳[1] 李琦 王金会[1] 赵培勇[1] 

机构地区：[1]威海市立医院,山东威海264200 [2]烟台市市直机关医院,山东烟台264000

出　　处：《中国药物警戒》2015年第6期357-359,362,共4页Chinese Journal of Pharmacovigilance

摘　　要：目的为临床安全合理使用芪苈强心胶囊提供参考依据。方法采用化学发光免疫检验技术测定地高辛血药浓度,对监测的结果进行统计分析。结果在监测的258例患者中,地高辛浓度<2 ng·m L-1的有235例(91.09%),地高辛浓度≥2 ng·m L-1的有23例(8.91%),其中洋地黄中毒者7例(2.71%)。年龄对地高辛浓度有显著性差异(P<0.05),性别对地高辛血药浓度无显著性差异(P>0.05)。结论监测地高辛浓度,制定个体化给药方案,对指导临床合理使用芪苈强心胶囊具有十分重要的意义。Objective To provide reference for safe, effective and reasonable use of Qiliqiangxin Capsules in clinic. Methods Serum digoxin concentration was determined by chemiluminescence immune inspection technology, and the monitoring results were subjected to statistical analysis. Results Of the total 258 cases who were treated with Qiliqiangxin Capsules, 91.09% serum digoxin concentrations were below 2 ng·mL-1, 8.91% were above 2 ng·mL-1, with 7 cases （2.71%） having symptoms of poisoning. The concentration in the group above the age of 60 years old was higher than that in the group under 60 years old （P〈0.05）. Sex had no perfect statistical mean （P〉0.05）. Conclusion To ensure clinical efficacy and reduce incidence of Qiliqiangxin Capsules, it＇s important to monitor the serum digoxin concentration.

关 键 词：芪苈强心胶囊 洋地黄过量 地高辛浓度 

分 类 号：R994.11[医药卫生—毒理学] R286[医药卫生—药学]