中药与来曲唑在肾虚血瘀型排卵障碍性不孕症患者中的联合应用  

Chinese Medicine Combined with Letrozole for Patients with Ovulation Disorder Infertility in Shenxu Xueyu Type

作　　者：程小林[1] 郭佶伟[2] 熊红[1] 

机构地区：[1]华中科技大学同济医学院附属武汉市普爱医院,武汉430033 [2]湖北省妇幼保健院,武汉430070

出　　处：《中国实验方剂学杂志》2015年第13期169-173,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：2004年武汉市卫生局基金项目(武卫[2004]241)

摘　　要：目的:探讨中药周期疗法与来曲唑在肾虚血瘀型排卵障碍性不孕症患者中的联合应用价值。方法:将92例肾虚血瘀型排卵障碍性不孕症患者随机按数字表分为治疗组和对照组各46例,对照组患者采用来曲唑的临床药物治疗,治疗组患者则在对照组治疗的基础上加用中药周期疗法的联合治疗方案,并分别对两组患者的临床治疗情况及血清睾酮(T),雌二醇(E2),黄体生成素(LH),卵泡刺激素(FSH)的含量进行比较和分析。结果:与对照组相比,研究组的痊愈率50.00%(23/46),总有效率91.30%(42/46)均显著提升;研究组治疗后的主卵泡直径(19.89±3.25)mm,子宫内膜厚度(9.72±1.86)mm均明显增加;研究组的排卵率76.09%,妊娠率45.65%,活胎率90.48%均明显提高,而流产率9.52%则明显降低;研究组治疗后的E2(240.26±58.72)pmol·L-1,FSH(16.23±4.25)U·L-1水平均明显提高,而T(1.69±0.30)nmol·L-1,LH(24.35±6.18)U·L-1,LH/FSH(1.51±0.73)水平则明显降低;研究组治疗后的中医证候积分(5.36±1.20)分明显将低;研究组中医证候疗效达到临床痊愈标准的比率54.35%(25/46)明显提高,总有效率95.65%(44/46)显著改善,差别均具有统计学意义(P<0.05)。结论:中药周期疗法联合来曲唑对于肾虚血瘀型排卵障碍性不孕症相关临床症状的改善以及临床治疗效果的提升均具有积极的促进作用,可作为肾虚血瘀型排卵障碍性不孕症临床治疗的理想方案予以推广。Objective： The aim of this study was to probe into the application value of the combination of Chinese medicine cycle treatment and letrozole for patients with ovulation disorder infertility in Shenxu Xueyu type. Method： The ninty-two patients with ovulatory disorder infertility in Shenxu Xueyu type were divided into treatment group and control group by digital form randomly. There were 46 cases in each group. The patients in the control group were treated with letrozole drug therapy. The patients in the treatment group were treated with letrozole combined with Chinese medicine cycle treatment. The clinical treatment of the patients in two groups were compared and analyzed. Result： Compared with control group,in treatment group,the recovery rate was 50. 00%（ 23 /46） and the total efficacy was 91. 30%（ 42 /46） with significant increase; after treatment,the primary follicular diameter was（ 19. 89 ± 3. 25） mm,the endometrial thickness was（ 9. 72 ± 1. 86） mm,both increased significantly; the ovulation rate was 76. 09%,pregnancy rate was 45. 65% and live birth rate was 90. 48%,all increased significantly; while the abortion rate was 9. 52%,which decreased significantly; after treatment,the levels of estradiol（ E2） was（ 240. 26 ± 58. 72） pmol·L- 1,follicle-stimulating hormone（ FSH） was（ 16. 23 ±4. 25） U·L- 1,which both increased significantly,while the level of testosterone（ T） was（ 1. 69 ± 0. 30） nmol·L- 1,luteinizing hormine（ LH） was（ 24. 35 ± 6. 18） U·L- 1,LH/FSH was（ 1. 51 ± 0. 73）,which all decreased significantly; after treatment, the scores of TCM syndrome was（ 5. 36 ± 1. 20） points, which reduced significantly; the ratio of TCM syndromes cure was 54. 35%（ 25 /46）,the total efficiency was 95. 65%（ 44 /46）,with both increased significantly. The differences were significant（ P〈0. 05）. Conclusion： Chinese medicine cycle treatment combined with letrozole has a positive role in promoting the clinical effects and improving the cl

关 键 词：中药周期疗法 来曲唑 肾虚血瘀型 排卵障碍性不孕症 

分 类 号：R287.6[医药卫生—中药学]