苯佐卡因合成实验的改进  

Improvement of Synthesis Experiment of Benzocaine

作　　者：秦永华[1] 张斌[1] 张雅娟[1] 张新波[1] 

机构地区：[1]浙江医药高等专科学校

出　　处：《化学教育》2015年第12期35-38,共4页Chinese Journal of Chemical Education

摘　　要：基于绿色化学理念,对传统基础有机化学实验苯佐卡因的制备进行了改进。以无溶剂法合成了离子液体乙基吡啶硫酸氢盐,用其代替浓硫酸作为酯化反应催化剂,同时考察了酸醇比、离子液体用量、反应时间及催化剂重复利用效率对反应的影响;使用钯碳-甲酸铵代替铁酸还原体系制备苯佐卡因,考察了钯碳用量对反应的影响,并简化了后处理过程。Based on the ideas of green chemistry, the synthesis of benzocaine, one of tradi- tional organic chemistry experiments, was improved in this article. The ionic liquid ethyl pyridine hydrogen sulfate was synthesized and used as the esterification catalyst instead of concentrated sulfuric acid. The effects of acid/alcohol ratio, amount of ionic liquid, reaction time and catalyst reuse on esterification were discussed. The process of after-treatment was simplied by the usage of Pd-C/HCOONH4 in the reducing atmosphere rather than iron-acid system, and also the a- mount of Pd-C on the reduction reaction was analyzed.

关 键 词：苯佐卡因 合成实验改进 离子液体 钯碳催化剂 绿色化学 

分 类 号：TQ463-4[化学工程—制药化工] G642[文化科学—高等教育学]