谷胺酰胺颗粒对慢性重症乙型肝炎患者肝功能和内毒素水平的影响  

The effect of glutamin on liver function and endotoxemia in severe chronic hepatitis B patients

作　　者：杨建荣[1] 宋怀宇[2] 姜春华[3] 

机构地区：[1]广西壮族自治区江滨医院,南宁530021 [2]广西壮族自治区人民医院,南宁530021 [3]南宁市第四人民医院,广西530000

出　　处：《中国临床新医学》2015年第6期500-503,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西医疗卫生重点科研课题(编号:重2008010)

摘　　要：目的观察慢性重症乙型肝炎患者应用小剂量谷胺酰胺颗粒后肝功能和内毒素水平的临床变化,评价小剂量谷胺酰胺颗粒应用于慢性重症乙型肝炎患者的可行性。方法 40例诊断慢性重症乙型肝炎明确的患者随机分为对照组和治疗组。对照组给予常规护肝、抗病毒和支持治疗;治疗组在对照组治疗的基础上加用小剂量谷胺酰胺颗粒5 g,tid,疗程均为14 d。观察两组慢性重症乙型肝炎患者治疗前后肝功能和内毒素水平的变化,并进行组间和组内对比分析。结果两组患者治疗前后对比,肝功能和内毒素水平均有所改善(P<0.01),但加用小剂量谷胺酰胺颗粒5 g,tid后,治疗组与对照组相比,肝功能和内毒素水平均无明显变化(P>0.05)。结论在慢性重症乙型肝炎患者治疗中加用小剂量谷胺酰胺颗粒未能起到进一步改善肝功能及内毒素血症的临床作用。Objective To study the effect of low dose glutamin on liver function and endotoxemia in severe chronic hepatitis B patients.Methods Forty patients with severe chronic hepatitis B were randomly divided into the control group and the experiment group.The control group received the conventional treatment and the experiment group received addiontional glutamine treatment（5 g tid）.The period of the treatment is two weeks.ALT, AST, TBIL, PT, A, CHE and endotoxin（ ET） were detected before and after treatment in the two groups respectively.Results The liver function and serum ET were both improved significantly after two weeks′treatment, compared with those before treatment in the two groups（P〈0.01）.Both of the two parameters had no significant difference between the two groups after the treatment（P〉0.05）.Conclusion Adding low dose glutamine（5 g tid） to the conventional treatment can not ameliorate the endotoxemia and liver function in patients with severe chronic hepatitis B.

关 键 词：慢性重症乙型肝炎 谷胺酰胺 肝功能 内毒素血症 

分 类 号：R512.62[医药卫生—内科学]