重组人干扰素α-2b栓联合光动力疗法治疗宫颈人乳头瘤病毒亚临床感染62例疗效评价  

Efficacy of Recombinant Human Interferon α-2b Suppository Combined with PDT for Treating HPV Subclinical Infection in 62 Cases

作　　者：庄另发[1] 赵莞[2] 盛飞凤[1] 

机构地区：[1]广东省妇幼保健院,广东广州510010 [2]广东省中医院,广东广州510000

出　　处：《中国药业》2015年第12期36-38,共3页China Pharmaceuticals

摘　　要：目的观察重组人干扰素α-2b栓联合5-氨基酮戊酸光动力疗法(ALA-PDT)治疗宫颈人乳头瘤病毒(HPV)亚临床感染的临床疗效。方法选择医院2013年6月至12月收治的HPV亚临床感染患者124例,随机分为治疗组和对照组,各62例。对照组患者给予重组人干扰素α-2b栓阴道塞入,每次1枚,隔日1次,连用15次;治疗组患者在对照组基础上加用ALA-PDT治疗。观察并记录两组疗效,检测并记录两组患者治疗前后血清肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)的浓度变化,随访治疗后3,6,12个月HPV转阴情况,记录治疗过程中不良反应发生情况。结果治疗组总有效率为96.77%,明显高于对照组的87.10%(P<0.05);两组患者TNF-α浓度均较治疗前明显下降,且治疗组下降幅度更显著(P<0.05);两组患者IL-6浓度均较治疗前明显升高,且治疗组升高幅度更显著(P<0.05);治疗组随访12个月后HPV总转阴率为98.39%,明显高于对照组的90.32%(P<0.05);两组患者治疗过程中不良反应发生率均较低,组间比较无明显差异(P>0.05)。结论重组人干扰素α-2b栓联合ALA-PDT治疗HPV亚临床感染,疗效可靠,可改善免疫情况,提高HPV转阴率,且不良反应少,值得临床推广。Objective To observe the clinical effect of Recombinant Human Interferon α-2b Suppository combined with 5-aminolevulinic acid-photodynamic therapy（ALA-PDT） in the treatment of human papillomavirus（HPV） subclinical infection. Methods Totally 124 patients with cervical HPV subclinical infection admitted to the hospital from June to December 2013 were selected and randomly divided into the treatment group and the control group,62 cases in each group. The control group was given Recombinant Hu-man Interferon α-2b Suppository by vaginal tract placing,one suppository each time,once every other day,for continuous 15 times;on this basis the treatment group was added with ALA- PDT. The curative effects were observed and recorded in both groups. The changes of serum TNF-α and IL-6 concentrations before and after treatment were detected and recorded in both groups. The HPV negative conversion situation after 3-,6-,12-month therapy was followed up. The occurrence situation of adverse reactions were recorded in the two groups. Results The total effective rate after treatment in the treatment group was 96. 77%,which was significantly higher than 87. 10% in the control group（ P 〈 0. 05）;the TNF-α concentration after treatment in both groups was significantly de-creased compared with before treatment,moreover the decrease amplitude in the treatment group was more significant（ P 〈 0. 05）,the IL-6 concentration after treatment in both groups was significantly increased compared with before treatment,moreover the increase am-plitude in the treatment group was more significant（ P 〈 0. 05）;the overall HPV negative conversion rate after 12-month follow up in the treatment group was 98. 39%,which was significantly higher than 90. 32% in the control group（ P 〈 0. 05）;the incidence rate of ad-verse reactions during the treatment process in both groups was lower without statistical difference between the two groups（ P 〉 0. 05）. Conclusion Recombinant Human Interferon α-2b Suppository combined wit

关 键 词：重组人干扰素Α-2B栓 5-氨基酮戊酸光动力疗法 宫颈人乳头瘤病毒 亚临床感染 

分 类 号：R969.4[医药卫生—药理学] R978.7[医药卫生—药学]