组蛋白去乙酰化酶抑制剂激活HIV储存库的研究进展  

Reactivation of latent HIV induced by histone deacetylase inhibitors

作　　者：白帆[1] 康文[1] 汪春付[1] 孙永涛[1] 

机构地区：[1]第四军医大学唐都医院传染科,西安710038

出　　处：《中国艾滋病性病》2015年第6期539-542,共4页Chinese Journal of Aids & STD

基　　金：国家"十二五"科技重大专项(2014ZX10001002)~~

摘　　要：即使是极早期接受规范化抗反转录病毒治疗(ART)的艾滋病病毒(HIV)感染者,HIV也会在CD+4T淋巴细胞中形成病毒储存库。储存库的形成与整合的前病毒的转录沉默相关,且至少部分由组蛋白去乙酰化酶(HDACs)所诱导。HDACs是一组染色质相关的蛋白质,可以调节组蛋白的乙酰化水平以及脱氧核糖核酸(DNA)与转录因子的亲和程度。值得注意的是,通过抑制HDACs的活性,可以有效地激活储存库中的HIV。这一发现衍生出"shock and kill"的设想,可能达到清除储存库的目的,也可能成为HIV功能性治愈的策略之一。Objective Latent HIV persists in resting CD＋ T cells in infected patients even with early antiretrovi- ral therapy （ART）. Latency is associated with transcriptional silencing of the integrated provirus and partially in- duced by histone deacetylases （HDACs）, a family of chromatin-associated proteins that regulate histone acetylation and the accessibility of DNA to transcription factors. Furthermore, inhibition of HDACs is efficient to reactivate a fraction of latent HIV. These findings promote the researches of the ＂shock and kill＂ strategy that might lead to the elimination of the pool of latently infected cells and a functional cure for HIV.

关 键 词：艾滋病病毒 潜伏感染 病毒储存库 组蛋白去乙酰化酶 组蛋白去乙酰化酶抑制剂 

分 类 号：R512.91[医药卫生—内科学]