Eu(Ⅲ)掺杂ZnS量子点室温磷光法测定生物体液中盐酸普萘洛尔  

Eu(Ⅲ)-Doped ZnS Quantum Dots for the Room-Temperature Phosphorescence Detection of Propranolol Hydrochloride in Biological Fluids

作　　者：毕霖[1] 于源华[1] 

机构地区：[1]长春理工大学生命科学技术学院,吉林长春130022

出　　处：《分析科学学报》2015年第3期401-404,共4页Journal of Analytical Science

基　　金：吉林省重大科技专项(No.10ZDGG0005)

摘　　要：在水相中合成了L-半胱氨酸包覆的Eu（Ⅲ）掺杂ZnS量子点（QDs）,基于盐酸普萘洛尔（PRO）对该量子点磷光的显著猝灭作用,建立了一种室温磷光（RTP）猝灭法测定生物体液中PRO的新方法。在最佳条件下,当PRO的浓度为5~500ng·mL^-1时,RTP变量（△IRTP）与其浓度呈现出良好的线性关系,检测限为4.18ng·mL^-1,5次平行测定的相对标准偏差为2.6%。该方法成功地应用于生物体液中PRO的测定,样品加标回收率为95%~101%。Eu（Ⅲ）-doped ZnS quantum dots（QDs）have been synthesized using L-cysteine as surface modifying agent in aqueous solution.The phosphorescence of the QDs can be quenched by propranolol hydrochloride（PRO）.Based on these findings,an RTP quenching method was developed for the sensitive and selective detection of PRO with Eu（Ⅲ）-doped ZnS QDs in biological fluids.Under the optimal conditions,the detection limit for PRO was 4.18ng·mL^-1.The relative standard deviation was 2.6%（c=10ng·mL^-1,n=5）.The proposed method was successfully applied in biological fluids with satisfactory results.The recovery of the method was in the range of 95%-101%.

关 键 词：Eu(Ⅲ)掺杂ZnS量子点 室温磷光 盐酸普萘洛尔 生物体液 

分 类 号：O657.39[理学—分析化学]