荔枝草的化学成分研究  

Chemical constituents of Salvia plebeia

作　　者：亢文佳[1] 富艳彬[1] 李达翃[1] 韩国华[1] 孙琳[1] 李占林[1] 华会明[1] 

机构地区：[1]沈阳药科大学中药学院教育部基于靶点的药物设计与研究重点实验室,辽宁沈阳110016

出　　处：《中草药》2015年第11期1589-1592,共4页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81172958)

摘　　要：目的研究荔枝草Salvia plebeia全草的化学成分。方法运用硅胶、Sephadex LH-20、开放ODS柱色谱和制备薄层色谱等方法进行分离纯化,并根据理化性质及波谱数据分析等手段鉴定化合物的结构。结果从荔枝草全草70%乙醇提取物中分离得到11个化合物,分别鉴定为5,6-二羟基-7,4′-二甲氧基黄酮(1)、5,6,3′-三羟基-7,4′-二甲氧基黄酮(2)、泽兰黄酮(3)、高车前苷(4)、芹菜素(5)、线蓟素(6)、6-甲氧基柚皮素(7)、大黄素(8)、马斯里酸(9)、isorosmanol(10)、(-)-epiloliolide(11)。结论其中化合物11为首次从该属植物中分离得到,化合物1、2、6、9、10为首次从该植物中分离得到。Objective To study the chemical constituents from the herb of Salvia plebeian. Methods The constituents were isolated and purified by silica gel, Sephadex LH-20, and ODS column chromatography, and preparative TLC. The structures of the isolated compounds were elucidated by spectroscopic analysis and physicochemical properties. Results Eleven compounds were isolated and purified from the ethanol extract of S. plebeia. They were identified as 5,6-dihydroxy-7,4′-dimethoxyflavone（1）, 5,6,3′-trihydroxy-7,4′-dimethoxyflavone（2）, nepetin（3）, homoplantaginin（4）, apigenin（5）, cirsiliol（6）, 6-methoxynaringenin（7）, emodin（8）, maslinic acid（9）, isorosmanol（10）, and（-）-epiloliolide（11）. Conclusion Among them, compound 11 is isolated from the plants of Salvia L. firstly, and compounds 1, 2, 6, 9, and 10 are isolated from S. plebeian for the first time.

关 键 词：荔枝草 5 6-二羟基-7 4′-二甲氧基黄酮 5 6 3′-三羟基-7 4′-二甲氧基黄酮 线蓟素 马斯里酸 (-)-epiloliolide 

分 类 号：R284.1[医药卫生—中药学]