体温控制用于保护感染性休克患者器官功能及改善预后的临床研究  

Clinical studies on temperature control for the organ function and prognosis of patients with septic shock

作　　者：林文基 吴莉梅 周南南 

机构地区：[1]深圳市南山区蛇口人民医院ICU室,深圳市518000 [2]深圳市宝安区宝安中医院社康中心,深圳市518000

出　　处：《中华实验和临床感染病杂志（电子版）》2015年第2期103-105,共3页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

摘　　要：目的探讨顽固性感染性休克患者采取不同程度的体温控制对其重要器官功能及预后的影响。方法收集2012年1月至2014年1月深圳市南山区蛇口人民医院ICU收治并确诊的50例顽固性感染性休克患者作为研究对象,采用控温毯,根据调控目标体温的不同,将入选患者分为观察组和对照组,比较两组患者的相关指标。结果治疗48 h后,两组患者治疗前后的白细胞计数、肌钙蛋白、凝血酶原时间(PT)、C-反应蛋白(CRP)、丙氨酸氨基转移酶(ALT)和血肌酐等指标进行比较,同组及组间进行比较,差异均具有统计学意义(P均<0.05)。治疗4周,两组患者的全身性感染相关性器官功能衰竭评分(SOFA)、ICU停留时间及病死率进行比较,除病死率外,差异均具有统计学意义(P均<0.05)。结论恰当的控制顽固性感染性休克患者的体温,对患者的重要器官功能具有保护作用。Objective To investigate the influence on the temperature control for the organ function and prognosis of patients with intractable septic thock.Methods Total of 50 cases with intractable septic shock were collected from January 2012 to January 2014 in ICU,Shekou People＇s Hospital of Nanshan District,Shenzhen.Thoes case were divided into observation group and control group according to different target temperature detected by the temperature control blanket.The related indicators of two groups were compared,respectively.Results The number of white blood cells,troponin,prothrombin time（PT）,C-reactive protein（CPR）,alanine aminotransferase（ALT） and serum creatinine were compared 48 hours after treatment,before and after treatment,with significant differences（P all 〈0.05）.The systemic infection related organ function failure score（SOFA）,length of stay in ICU and mortality of two groups were compared at treatment of 4 weeks,with the exception of the mortality,were all with significant differences（P all 〈0.05）.Conclusions Appropriate temperature control for patients with refractory septic shock have a protective effect on vital organs.

关 键 词：顽固性感染性休克 控温毯 目标体温 预后 

分 类 号：R631.4[医药卫生—外科学]