用数字离子阱进行快速质量分析  

Rapid Mass Analysis of Reserpine and Arginine by Ion Trap Mass Spectrometer

作　　者：徐福兴[1,2] 党乾坤 陈银娟[2] 杨凯[3] 王强[3] 陈斌[3] 汪源源[1] 丁传凡[2] 

机构地区：[1]复旦大学电子工程系,上海200433 [2]复旦大学化学系激光化学研究所,上海200433 [3]中国环境监测总站,北京100012

出　　处：《分析化学》2015年第6期949-954,共6页Chinese Journal of Analytical Chemistry

基　　金：科技部十二五重大科学仪器设备开发专项项目(Nos.2011YQ14015006;2011YQ06010003;2011YQ14014703)资助

摘　　要：利用数字离子阱技术进行样品的快速质量分析。在样品离子被引入离子阱的过程中,同时扫描数字射频工作电压的频率和离子共振偶极电压的频率,使得离子在进入离子阱质量分析器后,立即被相应的共振偶极电压所共振激发而逐出离子阱,并被离子探测器测量到。本方法相较于传统离子阱分析过程省去了离子引入、离子冷却和离子清空3个阶段,减少了约3/4的实验分析时间。通过对扫描速度、离子门电压参数的优化,数字束缚射频频率从1000~400 k Hz线性扫描,扫描速度为2385 Th/s,离子门电压为9 V,对利血平（m/z 609）,精氨酸（m/z 174）等样品的进行测试,离子信号强度达到最优。结果表明,利用本方法可以获得与离子阱质量分析传统方法相同的质谱结果。An experimental method of fast mass analysis using digital ion trap technology was reported. The mass analysis was realized by scanning the frequency of digital RF voltage and dipole ion resonance voltage in ion injection process without conventional ion cooling, ion resonance ejection or ion cleaning process, decreasing about three fourth in traditional analysis time. The signal could be optimized through modification of frequency scanning rate, ion gate voltage and other exper/mental parameters. In this study, the optimal signal of reserpine （m/z 609 ） and arginine （m/z 174） was obtained when ion gate voltage was 9 V and frequency of digital RF voltage was linearly scanned from 1 MHz to 400 kHz at rate of 2385 Th/s. It was found that mass spectrometric results were in good agreement with that by traditional analytical method.

关 键 词：离子阱质谱 数字离子阱 质量扫描 快速分析 

分 类 号：O657.63[理学—分析化学]