1,2-苯并异噻唑啉-3-酮-壳聚糖缓释微球的制备及其性能研究  

Preparation and property of 1,2-benzo-isothiazolin-3-ketone/chitosan controlled release microsphere

作　　者：李志宏[1] 梁国雷 关静[1] 黄姝杰[1] 武继民[1] 张西正[1] 

机构地区：[1]军事医学科学院卫生装备研究所,天津300161

出　　处：《化工新型材料》2015年第6期77-79,共3页New Chemical Materials

基　　金：天津市自然科学基金重点项目(13JCZDJC33400);国家自然科学基金面上项目(31271007)

摘　　要：利用乳化交联法制备了1,2-苯并异噻唑啉-3-酮-壳聚糖缓释微球,通过扫描电子显微镜（SEM）、动态光散射（DLS）、傅里叶变换红外光谱（FT-IR）、X射线衍射和热重-差热分析等检测手段考察分析了微球的性能,并通过体外模拟释放探讨了其控释性能。结果表明：所制备的微球表面光滑,成球性好,分散性能优异,微球粒径主要集中在3~8μm范围内,BIT分子以物理包埋的方式与壳聚糖分子之间相结合,并被壳聚糖分子完全包裹;模拟释放实验表明,BIT-CSM可实现BIT的长期稳定释放,具有一定的控释效果。1,2-benzo-isothiazolin-3-ketone/chitosan microspheres（BIT-CSM）were prepared by emulsion crosslinking method with orthogonal experiment.Scanning electron microscopy,dynamic light scattering（DLS）,fourier transform infrared spectroscopy,X-ray diffraction and Thermogravimetric-differential thermal analysis were employed to investigate the morphology,chemical composition and thermal stability of the BIT-CSM.And the controlled release profile in vitro was analyzed through UV spectrophotometryassay.The results showed that the BIT-CSM were achieved and the microspheres seemed to be smooth and uniform with particle size 3-8μm while 1,2-benzo-isothiazolin-3-ketone were acquired by chitosan as molecule.And the BIT-CSM can supporta controlled release of BIT.

关 键 词：1 2-苯并异噻唑啉-3-酮 壳聚糖 微球 控释 

分 类 号：O636[理学—高分子化学]