气管内滴入硝普钠对新生儿持续肺动脉高压的临床治疗体会  

Treatment experience of intratracheal instillation of sodium nitroprusside on persistent pulmonary hypertension of the newborns(PPHN)

作　　者：李剑峰[1] 张应金[1] 刘佳[1] 梁凤潇[1] 

机构地区：[1]暨南大学附属顺德妇幼保健院,广东佛山528300

出　　处：《临床药物治疗杂志》2015年第3期86-89,共4页Clinical Medication Journal

摘　　要：目的:探讨气管内滴入硝普钠治疗新生儿持续肺动脉高压(PPHN)的临床疗效。方法:选取暨南大学附属顺德妇幼保健院2012年9月至2014年9月收治的40例新生儿持续肺动脉高压患儿随机分为两组各20例,其中对照组给予头罩加压吸氧、抗凝、强心等基础治疗;观察组在对照组基础上气管内滴入一氧化氮供体硝普钠,观察比较两组的治疗效果以及治疗前后动脉血氧分压(Pa O2)和平均肺动脉压(PAMP)。结果:观察组治疗有效率为75%,高于对照组的5%,两组比较差异有统计学意义(χ2=20.42,P<0.05),对照组治疗前平均PAMP为(24.45±3.65)mm Hg,治疗后为(24.55±3.75)mm Hg,治疗前平均Pa O2(43.25±4.33)mm Hg,治疗后平均Pa O2(43.13±4.55)mm Hg,前后P>0.05,治疗前后结果无改变;观察组平均PAMP(25.95±3.35)mm Hg,PAMP(18.55±2.45)mm Hg,实验前平均Pa O2(45.66±4.73)mm Hg,试验后平均Pa O2(63.13±5.55)mm Hg,前后P<0.05,结果提示差异巨大,气管内滴入硝普钠对治疗新生儿持续肺动脉高压有临床意义。结论:气管内滴入硝普钠有利于治疗新生儿持续肺动脉高压,其临床效果明显,简单经济,能迅速解决持续动脉高压状态,提高血氧含量,适合临床推广应用。Objective：To investigate the clinical efficacy of intratracheal instillation of sodium nitroprusside on treating persistent pulmonary hypertension of the newborns.Methods：40 cases of newborns with persistent pulmonary hypertension from September 2012 to September 2014 in our hospital were collected.They were randomly divided into two groups with 20 cases in each group.The control group was treated with pressurized oxygen,anticoagulation and cardiac glycoside treatment,and those in the observation group were treated with additional intratracheal instillation of an equal amount of NO donor sodium nitroprusside.The effect of treatment and arterial oxygen partial pressure（Pa O2） and mean pulmonary arterial pressure（PAMP） before and after the traetment between the two groups.Results：Effective rate of the observation group was 75%,higher than that of the control group（5%）,and there was a significant difference between two groups（χ^2=20.42,P0.05）.As for the control group,the pre-and post-treatment average PAMP were（24.45 ± 3.65） mm Hg and（24.55 ± 3.75） mm Hg）,and the pre-and post-treatment average Pa O2 were（43.25 ± 4.33 mm Hg） and（43.13 ± 4.55） mm Hg.The comparison of the data of pre-and post-treatment showed that the treatment for the control group had no change（P〈0.05）.For the observation group,the preand post-treatment average PAMP were（25.95 ± 3.35） mm Hg and（18.55 ± 2.45） mm Hg,and the pre-and post-treatment average Pa O2were（45.66 ± 4.73） mm Hg and（63.13 ± 5.55）.The comparison of the data of pre-and post-treatment showed that the treatment for the observation group had a significant difference（P〈0.05）.There was a clinically significance of intratracheal instillation sodium nitroprusside for the treatment of persistent pulmonary hypertension of the newborns.Conclusion：Intratracheal instillation of sodium nitroprusside helps treat neonatal persistent pulmonary hypertension with obvious clinical efficacy.The method is simple and economic,

关 键 词：硝普钠 新生儿持续性肺动脉高压 临床体会 气管內滴入 

分 类 号：R978.7[医药卫生—药品] R512.62[医药卫生—药学]