福建汉族人群21个常染色体STR基因座的遗传多态性  

Genetic Polymorphisms of 21 Autosomal STR Loci of Fujian Han Population

作　　者：练惠辉[1] 戈文东[1] 林峰[1] 李斌[1,2] 

机构地区：[1]福建省公安厅物证鉴定中心福建省刑事科学技术重点实验室,福建福州350003 [2]福建医科大学附属协和医院,福建福州350001

出　　处：《法医学杂志》2015年第3期211-214,共4页Journal of Forensic Medicine

基　　金：福建省自然科学基金资助项目(2014J01273)

摘　　要：目的调查福建汉族人群21个常染色体STR基因座多态性参数，评估GlobalFiler^TM Express试剂盒的法医学应用价值。方法应用GlobalFiler^TM Express试剂盒复合扩增检测741名福建汉族无关个体，计算21个常染色体STR基因座的群体遗传学参数。结果21个常染色体STR基因座的基因型分布均符合Hardy-Weinberg平衡（尸〉0．05），21个STR遗传标记均具有高度多态性，杂合度为0．589～0．914，个体识别率为0．754～0．992，多态信息含量为0．520-0．940，非父排除率为0．278-0．825。其中以SE33基因座多态性程度最高。结论GlobalFiler^TM Express试剂盒的21个STR基因座有较强的系统效能，该试剂盒可应用于福建汉族人群的法医学个体识别及亲权鉴定。Objective To investigate the genetic polymorphisms of 21 autosomal STR loci of Fujian Han population and evaluate the forensic application value of GlobalFilerTM Express kit. Methods Amplified with GlobalFilerTM Express kit, DNA samples were obtained from 741 unrelated individuals of Fujian Han population. The population genetics parameters of 21 autosomal STR loci were calculated. Results The 21 autosomal STR loci were found to be no deviation from Hardy-Weinberg equilibration （P〉0.05） and relatively abundant in high polymorphism. Heterozygosity ranged from 0.589 to 0.914, power of dis- crimination ranged from 0.754 to 0.992, polymorphic information content ranged from 0.520 to 0.940, and power of exclusion ranged from 0.278 to 0.825. The SE33 locus was the highest degree in poly- morphism. Conclusion The 21 STR loci of GlobalFilerTM Express kit have high value in discrimination power and can be useful in personal identification and paternity test in Fujian Han population.

关 键 词：法医遗传学 多态现象 遗传 GlobalFiler^TM Express试剂盒 福建 汉族 

分 类 号：DF795.2[医药卫生—法医学]