红归胶囊联合化疗改善恶性肿瘤患者免疫功能的疗效观察  

Clinical observation of Honggui Capsules combined with chemotherapy in improvement of immune function in patients with malignant tumor

作　　者：王彬[1] 张凤云[1] 李小园[1] 王靖[1] 刘洋[1] 

机构地区：[1]牡丹江医学院第二附属医院医保科,黑龙江牡丹江157015

出　　处：《现代药物与临床》2015年第6期696-699,共4页Drugs & Clinic

基　　金：牡丹江市科学技术计划项目(Z2014S085)

摘　　要：目的：观察红归胶囊联合化疗改善恶性肿瘤患者免疫功能的临床疗效。方法选取2013年12月—2014年12月牡丹江医学院第二附属医院恶性肿瘤患者180例，随机分为对照组和治疗组，每组90例。对照组单纯化疗。治疗组在对照组治疗基础上口服红归胶囊，4粒/次，3次/d。两组21 d为1个疗程，共治疗3个疗程。两组患者在治疗前后测定OT皮试反应能力及巨噬细胞吞噬率。结果治疗组OT皮试反应能力增强5～10倍、10～20倍、20倍以上的患者例数明显多于对照组，无变化和下降病例数低于对照组，两组比较差异有统计学意义（P＜0.05）。巨噬细胞吞噬率增强10%～20%、20%～30%、30%以上的患者例数明显多于对照组，无变化和下降病例数低于对照组，两组比较差异有统计学意义（P＜0.05）。结论红归胶囊在对提高肿瘤患者的细胞免疫功能具有显著疗效，具有一定的临床价值。Objective To investigate the efficacy of Honggui Capsules combined with chemotherapy in improvement of immune function in patients with malignant tumor.Methods Patients （180 cases） with malignant tumor inthe Second Affiliated Hospital of Mudanjiang Medical University from December 2013 to December 2014 were randomly divided into control and treatment groups. Each group had 90 cases. Patients in control group were given chemotherapy only. Patients in treatment group werepo administered with Honggui Capsules on the basis of control group, 4 grains/time, three times daily. One course of treatment was 21 days, and two groups were treated for three courses of chemotherapy. Skin reaction ability about OT test and macrophage phagocytosis rates in two groups was conducted.Results The patients of skin reaction ability about OT test enhancing 5 — 10 times, 10 — 20 times, more than 20 times in the treatment group were significantly more than those in the control group, while the patients of no changing and falling were lower than those in the control group, and there were differences between two groups （P〈 0.05）. The patients of macrophage phagocytosis rate increasing 10% — 20%, 20% — 30%, more than 20% were significantly more than those in the control group, while the patients of no change and falling were lower than those in the control group, and there were differences between two groups （P〈 0.05）.Conclusion Honggui Capsules has the good clinical effect in improvement of immune function in patients with malignant tumor, which has certain clinical value.

关 键 词：红归胶囊 恶性肿瘤 OT皮试反应能力 巨噬细胞吞噬率 

分 类 号：R979.1[医药卫生—药品]