六神丸抑制AOM/DSS诱导小鼠炎症相关性结直肠癌的作用  

Inhibitory effects of Liushen Pill on AOM/DSS induced inflammation associated colorectal cancer in mice

作　　者：蔡杰[1] 包益洁 于卉[1] 石晓静[1] 邹瑜[1] 汤庆丰[1] 殷佩浩[1] 

机构地区：[1]上海中医药大学附属普陀医院普外科,上海200062

出　　处：《武警后勤学院学报（医学版）》2015年第6期424-426,F0003,共4页Journal of Logistics University of PAP（Medical Sciences）

基　　金：上海市普陀区科委创新重大项目(2011PTKW001);上海市科委动物专项子课题(13140903603);上海中医药大学中西医结合一流学科创新基金项目

摘　　要：【目的】探讨六神丸治疗AOM/DSS诱导小鼠炎症相关性结直肠癌的作用。【方法】建立AOM/DSS诱导小鼠炎症相关性结直肠癌模型并随机分为4组:生理盐水组、奥沙利铂组、六神丸组、非模型组。比较治疗后各组小鼠的肿瘤生长、胸腺和脾脏大小及对肠癌组织β-catenin表达的影响。【结果】经过4周给药后,奥沙利铂组和六神丸组的病灶数、病理表现、胸腺脾脏大小及β-catenin表达,均较生理盐水组有好转,差异有统计学意义(P<0.05),两组之间比较差异无统计学意义。【结论】六神丸可以抑制小鼠炎症相关性结直肠癌的形成,其抗小鼠炎症相关性结直肠癌效果明显。[Objective]To explore the effects of Liushen Pill on treating AOM/DSS induced inflammation associated colorectal cancer in mice. [Methods] Mouse models of AOM/DSS induced inflammation associated colorectal cancer were established and randomly divided into 4 groups by intragastric administration： normal saline group, oxaliplatin group, Liushen Pill group, non-model group. After the treatment, we compared the tumor growth of mice in each group, the sizes of thymus and spleen, as well as the effects of colorectal cancer β-catenin expression. [ Results ] After 4-week treatment, the number of tumors, pathological manifestation, the sizes of thymus and spleen, as well as β-catenin expression in oxaliplatin group and Liushen Pill group were better than those in normal saline group. The difference was statistically significant （P〈 0.05）. However the difference between the two groups was not statistically significant. [ Conclusion ] Liushen Pill can inhibit the genesis of inflammation associated colorectal cancer in mice. Its efficacy is obvious.

关 键 词：炎症相关性结直肠癌 六神丸 实验研究 

分 类 号：R289.55[医药卫生—方剂学]