Injectable Supramolecular Hydrogels via Inclusion Complexation of m PEG-grafted Copolyglutamate with α-Cyclodextrin  

作　　者：Lian-ying Wu Lei Yu Xiao-hui Fu 李志波 

机构地区：[1]Laboratory of Polymer Physics and Chemistry,Institute of Chemistry,Chinese Academy of Sciences

出　　处：《Chinese Journal of Polymer Science》2015年第8期1140-1149,共10页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Fund for Distinguished Young Scholars(No.51225306);the National Natural Science Foundation of China(No.21434008)

摘　　要：A series of monomethoxy poly（ethylene glycol） （mPEG） grafted copolyglutamates （PmPEGs） were synthesized through ring-opening polymerization （ROP） followed by click chemistry. Supramolecular hydrogels based on polymer inclusion complexes （ICs） between PmPEG and α-cyclodextriri （α-CD） were prepared in aqueous solution. The rheological measurements indicated their gelation properties were affected by several factors including the mPEG length, graft density and the sample concentration. These hydrogels displayed thermo-sensitive gel-sol transition under appropriate conditions due to the reversible mPEG and α-CD inclusion complexation. These hydrogels also showed pH-sensitive behavior due to the deprotonate of carboxylic acid side groups. The ICs formation of a channel-type crystalline structure induced gelation mechanism was verified by various techniques. In vitro cytotoxicity assays demonstrated that the supramolecular hydrogels are nontoxic and cytocompatible.A series of monomethoxy poly（ethylene glycol） （mPEG） grafted copolyglutamates （PmPEGs） were synthesized through ring-opening polymerization （ROP） followed by click chemistry. Supramolecular hydrogels based on polymer inclusion complexes （ICs） between PmPEG and α-cyclodextriri （α-CD） were prepared in aqueous solution. The rheological measurements indicated their gelation properties were affected by several factors including the mPEG length, graft density and the sample concentration. These hydrogels displayed thermo-sensitive gel-sol transition under appropriate conditions due to the reversible mPEG and α-CD inclusion complexation. These hydrogels also showed pH-sensitive behavior due to the deprotonate of carboxylic acid side groups. The ICs formation of a channel-type crystalline structure induced gelation mechanism was verified by various techniques. In vitro cytotoxicity assays demonstrated that the supramolecular hydrogels are nontoxic and cytocompatible.

关 键 词：Supramolecular hydrogel Inclusion complexation Copolyglutamate α-Cyclodextrin. 

分 类 号：O648.17[理学—物理化学] O636.12[理学—化学]